心肌肥厚大鼠外周血中CGRP和IL-6的表达变化

目的：探讨大鼠心肌肥厚形成过程中外周血降钙素基因相关肽（CGRP）和白介素-6（IL-6）的变化及意义。方法：参照Ander－son方法制作压力负荷性心肌肥厚大鼠模型，采用放免法检测大鼠不同时间点外周血CGRP、IL-6的浓度，电子天平称量左心室重，计算心重指数（LVW/BW）。结果：①模型组IL-6的浓度高于对照组（P<0.05），与心重指数呈正相关；②模型组CGRP的浓度均低于对照组（P<0.05），与心重指数呈负相关。结论：①伴随着心肌肥厚的发生发展，外周血中IL-6浓度增加；CGRP浓度减少；②CGRP和IL-6与心肌肥厚关系密切。

CGRP and IL-6 changes in the whole process of over-loaded heart hypertrophy

Objective:To investigate the significance of changes in peripheral blood calcitonin gene-related peptide (CGRP) and Interleukin-6 (IL-6) from the increasing of load to hypertrophy . Methods: The partial abdominal aorta ligature was used to induce hypertrophy in rats. CGRP and IL-6 were determined with radio immunological assay. The left ventricular weight was weighed with electronic balance. Result: Comparing with control rats, The level of IL-6 increased greatly in rats with ventricular hypertrophy (P<0.05).There was positive correlation of CGRP with degree of left ventrical hypertrophy(P<0.05). Conclusion:With the development of left ventricular hypertrophy, the level of IL-6 in peripheral blood increased and the level of CGRP decreased;The level of CGRP and IL-6 was related with the lift ventricular hypertrophy.