腹腔感染后维生素A、E、C代谢障碍的防治

目的观察完全胃肠外营养(TPN)添加维生素A、E、C对腹腔感染后抗氧化能力的影响。方法采用盲肠结扎加穿孔(CLP)模型,将SD大鼠随机分为对照组(CLP TPN)、治疗组(CLP TPN 维生素A、E、C)、延迟治疗组(CLP TPN 延迟应用维生素A、E、C),于术后当天以及第1、3、5天观察血浆及肝组织中维生素含量及丙二醛(MDA)、还原型谷胱甘肽(GSH)的变化。结果 CLP对照组维生素A、E、 C及GSH明显低于正常对照,MDA显著高于正常对照;治疗组和延迟治疗组维生素A、E、C及GSH显著高于对照组,但延迟治疗组低于治疗组;治疗组和延迟治疗组MDA明显低于对照组,但延迟治疗组高于治疗组。结论 TPN添加维生素A、E、C能改善腹腔感染后机体的抗氧化能力,减轻脂质过氧化损伤。

Effects of vitamins A, E, and C with total parenteral nutrition (TPN) on antioxidation in peritoneal sepsis

Objective To study the effects of vitamins A, E, and C with TPN on antioxidation in peritoneal sepsis. Methods The rat model of intraperitoneal infection was established by cecal ligation and puncture (CLP). Health male SD rats were divided into control group (CLP TPN), treatment group (CLP TPN Vitamin A, E, C), and delayed-treatment group ( CLP TPN delayed use of Vitamin A, E, C). Levels of the vitamins, MDA, and GSH in plasma and liver were measured. Results Vitamins A, E, C and GSH in the control group were lower than those in the normal control, and MDA was higher. Vitamins A, E, C and GSH in plasma and the liver in the treatment group and delayed-treatment group were higher than those in the control group, but delayed-treatment group was lower than treatment group. MDA in the treatment group and delayed-treatment group was lower than that in control group, but delayed-treatment group was higher than treatment group. Conclusion Vitamins A, E, C with TPN may effectively ameliorate the oxidative injuries in peritoneal sepsis.