| 慢性肝炎患者血清白细胞介素-18水平的检测 |
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| 引用本文： | 李新伟,周伟,张群芝. 慢性肝炎患者血清白细胞介素-18水平的检测[J]. 职业卫生与病伤, 2014, 0(2): 138-140 |
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| 作者姓名： | 李新伟 周伟 张群芝 |
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| 作者单位： | 漯河医学高等专科学校,河南漯河462000 |
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| 摘 要： | 目的探讨慢性肝炎患者血清中白细胞介素-18（IL-18）水平的变化规律及其临床意义。方法采用ELLSA法检测30例慢性肝炎患者活动期及30例缓解期、16例正常对照血清IL-18的水平。结果慢性肝炎活动期IL-18水平显著高于正常对照（P〈0.05）,与缓解期比较差异无统计学意义,缓解期与正常对照比较差异无统计学意义（P〉0.05）,IL-18水平与血清胆红素水平呈正相关（r=0.510,P〈0.05）。结论 IL-18参与慢性肝炎免疫致病过程,与肝炎病情活动相关。
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| 关 键 词： | 慢性肝炎 白细胞介素-18 |
Detection of Serum Level of IL-18 in Patients With Chronic Hepatitis |
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| Affiliation: | LI Xin - wei, ZHOU Wei, ZHANG Qun - zhi (Luohe Junior Medical College, Luohe 462000, Henan Province, China.) |
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| Abstract: | Objective To investigate the change and clinical significance of IL-18 levels in patients with chronic hepatitis. Methods Serum level of IL-18 was measured in 32 active and remissive phases of chronic hepatitis and 16 cases of healthy individuals（ as normal controls） by ELISA. Results Serum level of IL-18 in 32 cases of active phases of chronic hepatitis was significantly higher than that in normal controls（ P〈0. 05）. Compared with remissive phases,there was no significantly difference. And no significantly difference was found between remissive phases and normal controls（ P〉0. 05）. Conclusion IL-18 participates in the immune pathogenic process of chronic hepatitis and is related to the activity of hepatitis disease. |
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| Keywords: | chronic hepatitis IL-18 |
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