某院近十年罗红霉素、克拉霉素、阿奇霉素致药物不良反应的回顾性分析

目的：分析某院近十年罗红霉素、克拉霉素、阿奇霉素致药物不良反应（ADR）的相关因素。方法：采用回顾性分析法，将这 3 种药品分为 3 组，即罗红霉素组、克拉霉素组、阿奇霉素组；分析内容包括患者年龄、性别的分布情况以及 ADR 发生类型、临床表现、停药情况等。结果：罗红霉素组、克拉霉素组致 ADR 患者中性别对比无差异，而阿奇霉素组患者中女性大于男性。 结论：临床医师处理罗红霉素、克拉霉素以及阿奇霉素致 ADR 治疗时，应根据患者实际情况选择合适的治疗药物及给药方法，在确保患者具有知情权并对其讲解可能发生 ADR。

Analysis of Adverse Drug Reactions of Roxithromycin,Clarithromycin and Azithromycin Nearly A Decade Usage in A Hospital

Objective： To analyze the adverse drug reactions induced by nearly a decade use of roxithromycin, clarithromycin, azithromycin in a hospital （ADR） and the related factors. Methods： A retrospective analysis was as follows, the 3 drugs were divided into 3 groups, namely, roxithromycin group , clarithromycin group, azithromycin group; analysis content included patient age, gender distribution and ADR types, clinical manifestations, stoping the medicine etc. Results： Roxithromycin, clarithromycin group in ADR there was no difference of gender, but in the azithromycin group female patients more than that of the male patients in ADR. Conclusions： clinicians dealing with ADR induced by roxithromycin, clarithromycin and azithromycin, should choose the appropriate drug therapy and medication according to the actual situation of patients, to ensure that patients have the right to know the incidence of ADR.