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| 阿德福韦对HBeAg阴性慢性乙型肝炎患者的病毒动力学影响 | |
| 引用本文： | 严喜章. 阿德福韦对HBeAg阴性慢性乙型肝炎患者的病毒动力学影响[J]. 中华医院感染学杂志, 2011, 0(18): 3934-3935 |
| 作者姓名： | 严喜章 |
| 作者单位： | 西安医学院第二附属医院感染科,陕西西安,710038 |
| 摘 要： | 目的观察阿德福韦治疗HBeAg阴性慢性乙型肝炎患者HBV-DNA动态变化。方法选择HBeAg阴性慢性乙型肝炎患者58例,口服阿德福韦酯10mg,1次/d,分别于治疗4、8、12、24、36、48周时检测病毒载量及肝功,并进行数据统计分析。结果随着治疗时间的延长,发生病毒学应答的例数增多;治疗4、8、12、24、36周时各个阶段发生病毒学应答的患者于治疗48周时的完全应答率分别为100.0%、100.0%、94.7%、86.7%、81.6%和77.3%。结论阿德福韦能够快速降低HBeAg阴性慢性乙型肝炎患者,血清HBV-DNA和ALT水平,越早获得病毒学应答的患者,其最终获得完全应答的可能性越大。 |
| 关 键 词： | 慢性乙型肝炎 HBeAg 病毒动力学 阿德福韦 |
Effect of adefovir on viral kinetics in patients with HBeAg negative chronic hepatitis B |
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| YAN Xi-zhang. Effect of adefovir on viral kinetics in patients with HBeAg negative chronic hepatitis B[J]. Chinese Journal of Nosocomiology, 2011, 0(18): 3934-3935 | |
| Authors: | YAN Xi-zhang |
| Affiliation: | YAN Xi-zhang(Second Affiliated Hospital,Xi′an Medical College,Xi′an, Shannxi 710038,China) |
| Abstract: | OBJECTIVE To observe the treatment effect of adefovir in patients with HBeAg negative chronic hepatitis B.METHODS Fifty-eight cases of chronic hepatitis B with HBeAg negative were treated with adefovir 10mg per day orally and the course of treatment was 48 weeks.HBV-DNA and liver function were examined at 4,8,12,24 and 48 weeks.The data were recorded and analyzed.RESULTS As treatment time prolonged,more case happened viral response.The absolute response rates at 48 weeks in patients happening viral response... |
| Keywords: | Chronic hepatitis B HBeAg Viral dynamics Adefovir |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |