| Toll样受体在先天性免疫反应中的作用 |
| |
| 引用本文： | 朱学农,谭玉文,张玉梅,李春凤,李福泉,谢顺利,黄英,史宪伟. Toll样受体在先天性免疫反应中的作用[J]. 免疫学杂志, 2006, 22(Z1): 37-41 |
| |
| 作者姓名： | 朱学农 谭玉文 张玉梅 李春凤 李福泉 谢顺利 黄英 史宪伟 |
| |
| 作者单位： | 云南农业大学动物科学技术学院,昆明,650201 |
| |
| 基金项目： | 国家自然科学基金;云南省自然科学基金 |
| |
| 摘 要： | 先天性免疫识别侵袭的微生物,引起宿主防御反应.然而,先天性免疫识别的分子机制还不清楚.最近,有人发现了Toll样受体家族(TLRs),并阐明了这些受体在微生物识别中的主要作用.TLR基因家族包括11个成员,也可能更多.每种引起TLR先天性免疫反应的微生物类型各不相同.先天性免疫的激活引起特定抗原获得性免疫的发展.因此,TLRs控制先天性免疫反应和获得性免疫反应.
|
| 关 键 词： | Toll样受体 先天性免疫 获得性免疫 激活 反应 |
| 文章编号： | 1000-8861(2006)03(S)-0037-05 |
| 修稿时间： | 2005-12-16 |
Roles of Toll-like receptors in innate immune responses |
| |
| ZHU Xue-nong,TAN Yu-wen,ZHANG Yu-mei,LI Chun-feng,LI Fu-quan,XIE Shun-li,HUANG Ying,SHI Xian-wei. Roles of Toll-like receptors in innate immune responses[J]. Immunological Journal, 2006, 22(Z1): 37-41 |
| |
| Authors: | ZHU Xue-nong TAN Yu-wen ZHANG Yu-mei LI Chun-feng LI Fu-quan XIE Shun-li HUANG Ying SHI Xian-wei |
| |
| Abstract: | Innate immunity recognizes invading micro-organisms and triggers a host defence response.However,the molecular mechanism for innate immune recognition was unclear.Recently,a family of Toll-like receptors(TLRs) was identified,and crucial roles of these receptors in the recognition of microbial components have been elucidated.The TLR family consists of 11 members and will be expanding.Each TLR distinguishes between specific patterns of microbial components to provoke innate immune responses.The activation of innate immunity then leads to the development of antigen-specific adaptive immunity.Thus,TLRs control both innate and adaptive immune responses. |
| |
| Keywords: | Toll-like receptor Innate immunity Adaptive immunity Activation Response |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
