Clinicopathologic Study of Angiogenesis in Japanese Patients with Breast Cancer |
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| Authors: | Takao Kato Tsunehito Kimura Ryuhei Miyakawa Shinichi Tanaka Akiho Fujii Kazuko Yamamoto Shingo Kameoka Kyoichi Hamano Makio Kawakami Motohiko Aiba |
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| Affiliation: | (1) Department of Surgery II, Tokyo Women’s Medical College, 8-1 Kawada-cho, Shinjuku-ku, Tokyo 162, Japan, JP;(2) Department of Surgical Pathology, Tokyo Women’s Medical College, 8-1 Kawada-cho, Shinjuku-ku, Tokyo 162, Japan, JP;(3) Department of Surgical Pathology, Tokyo Women’s Medical College, Daini Hospital, Tokyo, 162, Japan, JP |
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| Abstract: | p = 0.0007) and tumor necrosis (TN) (HMC: p = 0.0050). Univariate analysis showed that AMC or HMC was a statistically significant predictor of overall survival in all patients ( p = 0.0086 and p = 0.0307, respectively). Multivariate analysis showed that AMC was an independent predictor of node status when we fitted a model with node status, BVI, and either AMC or HMC; but HMC was not independent. However, when we fitted a model including all 11 of the other indicators and AMC or HMC, the node status, HG, and LI were independent predictors, but AMC and HMC were not. Although AMC was a better method than HMC for evaluating angiogenesis, we cannot confirm angiogenesis as a significant independent prognostic factor associated with long-term survival in Japanese breast cancer patients. |
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