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| 睫状神经营养因子对大鼠创伤性脊髓水肿的影响 | |
| 引用本文： | 许斌,贾连顺,李家顺,何成,吴宏. 睫状神经营养因子对大鼠创伤性脊髓水肿的影响[J]. 医学研究生学报, 2002, 15(3): 210-212 |
| 作者姓名： | 许斌 贾连顺 李家顺 何成 吴宏 |
| 作者单位： | 1. 南京军区南京总医院军区骨科中心,江苏南京,210002 2. 第二军医大学附属长征医院骨科,上海,200003 3. 第二军医大学神经生物学教研室,上海,200433 4. 福建省立医院骨科,福建福州,350001 |
| 基金项目： | 国家自然科学基金资助项目 (批准号 :395 0 0 44) |
| 摘 要： | 目的 :观察睫状神经营养因子 (CNTF)对大鼠创伤性脊髓水肿的影响及其可能的作用机制。 方法 :采用改良Allen打击法致SD大鼠T8脊髓损伤 ,分别于术前及术后 3天用干湿法测定脊髓组织水含量、用原子吸收分光光度计测定脊髓组织中Ca2 的含量。 结果 :脊髓损伤后局部组织含水量、Ca2 含量均显著增加 (P <0 .0 1) ,用CNTF治疗后水含量、Ca2 含量有明显下降 (P <0 .0 1) ,但和正常组相比仍有明显差异。 结论 :CNTF可能是通过阻止Ca2 内流、稳定细胞内外Ca2 平衡而起到减轻创伤性脊髓水肿的作用。 |
| 关 键 词： | 脊髓损伤 脊髓水肿 睫状神经营养因子 |
| 文章编号： | 1008-8199(2002)03-0210-03 |
| 修稿时间： | 2001-05-18 |
Effects of ciliary neurotrophic factor on spinal cord edema in rats |
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| XU Bin ,JIA Lian shun ,LI Jia shun ,HE Cheng ,WU Hong. Effects of ciliary neurotrophic factor on spinal cord edema in rats[J]. Bulletin of Medical Postgraduate, 2002, 15(3): 210-212 | |
| Authors: | XU Bin JIA Lian shun LI Jia shun HE Cheng WU Hong |
| Affiliation: | XU Bin 1,JIA Lian shun 2,LI Jia shun 2,HE Cheng 3,WU Hong 4 |
| Abstract: | Objectives:To evaluate the effect and mechanism of ciliary neurotrophic factor (CNTF) on spinal cord edema in rats. Methods:SD rats were subjected to incomplete spinal cord injury (SCI) with modified Allen method. Contents of spinal cord tissue water and Ca 2 were measured preoperatively and 3 days after SCI. Results:There were significant increases in the contents of spinal cord tissue water and Ca 2 after injury, which were decreased obviously after treated with CNTF ( P < 0.01). Conclusions:CNTF may relieve spinal cord edema by regulating the balance of extracellular and intracellular calcium. |
| Keywords: | Spinal cord injury Spinal cord edema Ciliary neurotrophic factor |
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