| 松潘乌头总碱的镇痛作用 |
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| 引用本文： | 刘铭佩.松潘乌头总碱的镇痛作用[J].中药药理与临床,2007,23(1):36-37. |
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| 作者姓名： | 刘铭佩 |
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| 作者单位： | 兰州大学第二医院药剂科,兰州,730030 |
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| 摘 要： | 目的:研究松潘乌头总碱(TAS)的镇痛作用机制。方法:采用小鼠热板法和大鼠甩尾法测定动物的痛阈,同时检测乙酸致痛小鼠脑组织NO、MDA含量及SOD活性。结果:icv TAS0.025mg/kg能明显提高小鼠、大鼠的痛阈;TAS能使乙酸致痛小鼠脑组织NO、MDA含量明显降低,SOD活性明显增强;CaCl2能拮抗TAS的镇痛作用,Ver则使之增强。结论:TAS的镇痛作用部位可能在中枢神经系统,其作用机制可能与影响Ca2 内流和减少NO、MDA含量,提高SOD活性有关。
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| 关 键 词： | 松潘乌头总碱 镇痛作用 Ca2 内流 |
| 文章编号： | 24044641 |
Studies on the mechanism of analgesic action of tatal alkaloids of Aconitum sungpanense Hand-Mazz. |
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| Liu Mingpei.Studies on the mechanism of analgesic action of tatal alkaloids of Aconitum sungpanense Hand-Mazz.[J].Pharmacology and Clinics of Chinese Materia Medica,2007,23(1):36-37. |
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| Authors: | Liu Mingpei |
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| Institution: | The Second Hospital of Lanzhou College , Lanzhou 730030 |
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| Abstract: | Objective:To study the mechanism of analgesic action of total alkaloids of Aconitum sungpanense Hand-Mazz(TAS).Methods:The pain threshold in mice and rats was determined by using analgesic assays of hot plate in mice and tail flicking in rats.To determine the nitric oxide(NO),the malondialdehyde (MDA) contemts,superoxide dismutase(SOD)activity in the brain tissue of acetic acid writhing mouse.Results:The pain threshold of mice and rats was elevated after icv TAS in a dose of 1/10 systemic effective dose (0.025mg/kg).TAS(0.5,0.25mg/kg,sc) could obviously lowered contents of NO and MDA,and increased SOD activity in the brain tissue of acetic acid writhing mouse.The analgesic action of TAS could be antagenized by CaCl2 and enhanced by verapamil.Conclusion:The site of analgesic action of TAS may be in the central nervous system.Its mechanism of analgesic action are relate to its influence on the transmembrace influx of Ca2 and reducing the output NO and removing free radicals. |
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| Keywords: | NO MDA SOD |
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