| A novel improved design for the first-generation glucose biosensor |
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| 作者姓名： | Wang J |
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| 作者单位： | Liu Jie，Wang J |
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| 摘 要： | A novel improved design for the first-generation glucose biosensor@Wang J
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A novel improved design for the first-generation glucose biosensor |
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| Wang J.A novel improved design for the first-generation glucose biosensor[J].ACTA Academiae Medicinae Nantong,2003(1). |
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| Authors: | Liu Jie Wang J |
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| Abstract: | The historical development of three generations of enzyme-based amperometric glucose biosensors are compared.A novel design of the first-generation glucose giosensor based on the use of metal-dispersed carbon paste electrode is described.Such a strategy enables remarkable selectivity and improved sensitivity,without excluding or destroying the endogenous electroactive interferences commonly associated with the first-generation glucose biosensor.It offers a strong,preferential electrocatalytic action towards the enzymatically-liberated hydrogen peroxide due to the proper selection of the transducer metal-dispersed material.On the other hand,a unique,non-polar pasting liquid allows efficient operation of the resulting glucose biosensor under severe depletion of oxygen or under a considerable period of thermal stress by providing an internal oxygen supply and establishing a micro-environment of the enzyme against thermoinactivation,respectively.Metal-dispersed carbon paste enzyme electrodes have thus become a promising new design of the first generation biosensors,especially for blood glucose measurements and other biotechnical applications due to their remarkable selectivity,high stability,low oxygen-dependence,and good dynamic performance. |
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| Keywords: | glucose biosensors enzyme electrode metal-dispersed carbon paste |
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