纳米羟基磷灰石人工骨在骨缺损修复中的临床应用研究

目的　探讨纳米羟基磷灰石人工骨（Nano-HA）修复骨缺损的临床效果。  方法　回顾性分析了2009年9月~2012年6月采用Nano-HA人工骨治疗的27例骨缺损患者，骨缺损范围为0.3cm×1.0cm ~3.0cm×6.5cm，人工骨植入量为3~15 g。部位包括肱骨、桡骨、尺骨、股骨、胫骨、跟骨。骨缺损原因包括骨折22例，骨肿瘤5例。分别在术后1周、1个月和3个月进行临床和X线片检查，观察治疗效果。  结果　随访时间11个月～26个月，平均18.5个月，骨缺损区Nano-HA与宿主骨直接愈合，相容性好，与原骨界面间无间隙，术后观察未见不良反应。  结论　Nano-HA人工骨具有良好的生物相容性，是一种理想的骨缺损修复材料。

Clinical application study of Nano-Hydroxyapatite artificial bone in bone defect repair

Objective　To study the clinical effect of nano-hydroxyapatite(Nano-HA) artificial bone on repairing bone defects.　Methods　From Sep. 2009 to Jun. 2012, 27 cases of bone defect were collected retrospectively. The bone defect ranged from 0.3cm×1.0cm to 3cm×6.5cm, which including the bone defects of humerus, radius, ulna, femur, tibia, and calcaneus. Among them, 22 cases suffered from fractures and 5 cases tumors. All patients were treated with Nano-HA artificial bone. Observation was applied on healing of wounds and X-ray exams preoperatively and postoperatively.　Results　The patients were followed up from 11 month to 26 months （averagely 18.5 months）. X-ray photo showed an integrity interface between Nano-HA and bone. Primary healing was obtained in all cases without any complication.　Conclusions　The Nano-HA artificial bone has a good biocompatibility. It may be an ideal artificial material to reconstruct bone defect.