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| 氨基末端脑钠肽前体预测早产儿症状性动脉导管未闭的价值 | |
| 引用本文： | 卢凯珊,郭小玲,吕峻峰,黄少励,杨春晖,邹志慧,陈志君,赖春华,杨冰岩. 氨基末端脑钠肽前体预测早产儿症状性动脉导管未闭的价值[J]. 中国当代儿科杂志, 2015, 17(11): 1160-1164. DOI: 10.7499/j.issn.1008-8830.2015.11.003 |
| 作者姓名： | 卢凯珊 郭小玲 吕峻峰 黄少励 杨春晖 邹志慧 陈志君 赖春华 杨冰岩 |
| 作者单位： | 卢凯珊;, 郭小玲;2., 吕峻峰;2., 黄少励;2., 杨春晖;2., 邹志慧;2., 陈志君;2., 赖春华;2., 杨冰岩;2. |
| 基金项目： | 广东省医学科学技术研究基金项目(B2015084)。 |
| 摘 要： | 目的 探讨氨基末端脑钠肽前体(NT-proBNP)预测早产儿症状性动脉导管未闭(sPDA)的价值。方法 选择2014年6月至2015年4月出生、胎龄≤32周、48 h内超声心动图确定存在动脉导管的早产儿为研究对象,监测其临床表现,于生后3 d及5 d检测血清NT-proBNP水平并行超声心动图检查,根据患儿临床表现、超声心动图结果分为sPDA组及非症状性动脉导管未闭(asPDA)组,分析血清NT-proBNP水平与超声指标的关系,比较两组间相同日龄血清NT-proBNP水平,ROC曲线确定血清NT-proBNP水平预测sPDA的敏感性、特异性。结果 共69例早产儿纳入研究,其中sPDA组13例,asPDA组56例。血清NT-proBNP水平与动脉导管管径、左房内径与主动脉根部内径比值(LA/AO)呈正相关关系(分别r=0.856、0.713,均 PPCI:0.892~1.000,PCI:0.848~1.000,P结论 NT-proBNP可能是动脉导管分流量的量化指标;生后3 d 及5 d血清NT-proBNP水平的检测均有助于早期预测sPDA。 |
| 关 键 词： | 动脉导管未闭 氨基末端脑钠肽前体 早产儿 |
| 收稿时间： | 2015-06-04 |
| 修稿时间： | 2015-08-03 |
Value of amino-terminal pro-brain natriuretic peptide as a predictive marker of symptomatic patent ductus arteriosus in preterm infants |
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| LU Kai-Shan,GUO Xiao-Ling,LV Jun-Feng,HUANG Shao-Li,YANG Chun-Hui,ZOU Zhi-Hui,CHEN Zhi-Jun,LAI Chun-Hu,YANG Bing-Yan. Value of amino-terminal pro-brain natriuretic peptide as a predictive marker of symptomatic patent ductus arteriosus in preterm infants[J]. Chinese journal of contemporary pediatrics, 2015, 17(11): 1160-1164. DOI: 10.7499/j.issn.1008-8830.2015.11.003 | |
| Authors: | LU Kai-Shan GUO Xiao-Ling LV Jun-Feng HUANG Shao-Li YANG Chun-Hui ZOU Zhi-Hui CHEN Zhi-Jun LAI Chun-Hu YANG Bing-Yan |
| Affiliation: | LU Kai-Shan;, GUO Xiao-Ling;2., LV Jun-Feng;2., HUANG Shao-Li;2., YANG Chun-Hui;2., ZOU Zhi-Hui;2., CHEN Zhi-Jun;2., LAI Chun-Hua;2., YANG Bing-Yan;2. |
| Abstract: | Objective To study the value of amino-terminal pro-brain natriuretic peptide (NT-proBNP) in predicting symptomatic patent ductus arteriosus (sPDA) in preterm infants. Methods Preterm infants born at a gestational age (GA) of ≤32 weeks and diagnosed with patent ductus arteriosus (PDA) by echocardiography within 48 hours after birth between June 2014 and April 2015 were selected as subjects. Their clinical manifestations were observed, and serum NT-proBNP levels were measured and echocardiography was performed at 3 and 5 days after birth. The infants were divided into sPDA group and asymptomatic PDA (asPDA) group based on their clinical manifestations and the results of echocardiography. The correlations between serum NT-proBNP level and echocardiographic indices were analyzed. Serum NT-proBNP levels were compared between the two groups. The receiver operator characteristic (ROC) curve was applied to determine the sensitivity and specificity of serum NT-proBNP in the prediction of sPDA. Results A total of 69 preterm infants were enrolled in this study, with 13 infants in the sPDA group and 56 infants in the asPDA group. Serum NT-proBNP level was positively correlated with the diameter of the arterial duct (r=0.856; Pr=0.713; PPPPConclusions NT-proBNP may be a quantitative index for shunt volume. The measurement of serum NT-proBNP levels on 3 and 5 days after birth may be useful to predict sPDA in preterm infants. |
| Keywords: | Patent ductus arteriosus|NT-proBNP|Preterm infant |
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