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Association of the HLA region with multiple sclerosis as confirmed by a genome screen using >10,000 SNPs on DNA chips
Authors:René Gödde  Klaus Rohde  Christian Becker  Mahammad R. Toliat  Patricia Entz  Anita Suk  Norbert Müller  Eckhart Sindern  Michael Haupts  Sebastian Schimrigk  Peter Nürnberg  Jörg T. Epplen
Affiliation:(1) Department of Human Genetics, Ruhr-University, 44780 Bochum, Germany;(2) Gene Mapping Centre (GMC), Max Delbrück Centre for Molecular Medicine, Berlin, Germany;(3) Department of Transfusion Medicine, Universitätsklinikum Essen, Essen, Germany;(4) Department of Neurology, Kliniken Bergmannsheil, Ruhr-University, Bochum, Germany;(5) Department of Neurology, Knappschaftskrankenhaus, Ruhr-University, Bochum, Germany;(6) Department of Neurology, St. Josef-Hospital, Ruhr-University, Bochum, Germany
Abstract:
Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system, with a complex genetic background. Here, we present a genome screen for association in small scale, employing 11,555 single nucleotide polymorphisms (SNPs) on DNA chips for genotyping 100 MS patients stratified for HLA-DR2+ and 100 controls. More than 500 SNPs revealed significant differences between cases and controls before Bonferroni correction. A fraction of these SNPs was reanalysed in two additional cohorts of patients and controls, using high-throughput genotyping methods. A marker on chromosome 6p21.32 (rs2395182) yielded the highest significance level, validating the established HLA-DR association.P. Nürnberg and J.T. Epplen contributed equally.
Keywords:
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