|
|||||
|
|
Neo-capsule tissue reactions in metal-on-metal hip arthroplasty |
|
| Authors: | Witzleb Wolf-Christoph Hanisch Uwe Kolar Nicole Krummenauer Frank Guenther Klaus-Peter |
| Affiliation: | a Department of Orthopaedic Surgery, University Hospital “Carl Gustav Carus”, Dresden, Germanyb Institute of Forensic Medicine, University Hospital “Carl Gustav Carus”, Dresden, Germanyc Clinical Epidemiology and Health Economy Unit at the Department of Orthopaedic Surgery, University Hospital “Carl Gustav Carus”, Dresden, Germany |
| Abstract: | Background Modern-generation metal-on-metal articulations have a high wear resistance and may therefore be able to improve the long-term performance of artificial joints. However, the biological effects are still under debate. This study was undertaken to review the histopathological changes in neo-capsule tissues of different metal-on-metal hip arthroplasties. Methods Neo-capsule tissue samples from 46 hips with modern second-generation metal-on-metal articulations (39 hip resurfacings and 7 non-cemented total hip replacements) with a variety of failure mechanisms were examined histopathologically and immunohistochemically. Results A distinct lymphocytic infiltration was found in all cases with in situ times of more than 7 months, consisting of CD20-positive B-lymphocytes and CD3positive T-lymphocytes and sometimes thinly distributed CD138-positive plasma cells without dominant T-cell or plasma cell infiltrates. Interpretation This distinct lymphocytic infiltration has not been reported in tissue analyses of metal- or ceramic-on-polyethylene hip replacements, and may therefore be considered to be a characteristic histological pattern of tissue reactions on metal particles and/or ions around metal-on-metal bearings. |
| Keywords: | |
| 本文献已被 InformaWorld PubMed 等数据库收录！ | |