An autopsy case of triple cancers including signet-ring cell carcinoma of the breast —Report of a rare case with reference to a review of the literature— |
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Authors: | Jun Misonou MD Makoto Kanda Takayoshi Miyake Tsugumichi Kawamura Isao Maekawa Houhei Hishiyama Tomoyoshi Atsuta |
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Institution: | (1) The Department of Pathology, Asahikawa Municipal Hospital, Hokkaido, Japan;(2) The Department of Internal Medicine, Asahikawa Municipal Hospital, Hokkaido, Japan;(3) The Department of Surgery, Asahikawa Municipal Hospital, Hokkaido, Japan;(4) Hokkaido Histopathology Center, Kita-ku Kita 16 Nishi 5, 001 Sapporo, Hokkaido, Japan |
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Abstract: | A 67 year old Japanese woman who had been suffering from general fatigue was diagnosed as having metastasis of signet-ring
cell carcinoma of the bone marrow from a biopsied specimen. A clinical effortive search to the systemic organs revealed a
tumor of 4×3 cm in size in the lower part of her left breast, which was subsequently diagnosed as the primary site histopathologically.
The patient was immediately treated surgically, however, her general condition generally deteriorated and she expired 5 months
after the operation. Autopsy revealed dissemination of tumor cells in the bone marrow, bilateral pleura, and soft tissue around
the operated site. The autopsy additionally revealed squamous cell carcinoma of keratinizing type in the uterine cervix and
well differentiated tubular adenocarcinoma in the gallbladder. A review of the literature revealed this case to be the first
reported case of triple cancers including signet ring-cell carcinoma of the breast, proven by autopsy in Japan. |
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Keywords: | breast cancer lobular carcinoma signet-ring cell carcinoma multiple cancers |
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