| 正交实验法优选左羟丙哌嗪滴丸的处方及制备工艺 |
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| 引用本文： | 王军.正交实验法优选左羟丙哌嗪滴丸的处方及制备工艺[J].广东药学院学报,2010,26(1):9-12. |
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| 作者姓名： | 王军 |
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| 作者单位： | 武汉大学人民医院,药学部,湖北,武汉,430060 |
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| 摘 要： | 目的优选左羟丙哌嗪（LP）滴丸的处方及制备工艺。方法以水溶性高分子材料PEG6000和PEG4000为主要基质,采用正交实验方法,以滴丸的圆整度、光洁度、丸重差异为主要验证指标,优选LP滴丸的最佳处方及制备工艺。结果最佳处方为：以PEG6000∶PEG4000（2.5∶1）为混合滴丸基质,液体石蜡为冷凝液,药物与基质配比为1∶4;最佳工艺为：药液温度95℃,冷凝液温度10℃,滴速50滴/m in,滴头内外径为1.2和1.4 mm。结论优选出的处方及工艺制备的LP滴丸质量理想,值得进一步研究。
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| 关 键 词： | 左羟丙哌嗪滴丸 正交实验 制备工艺 |
Study on the optimal formulation and preparation process of levodropropizin dropping pills by orthogonal design |
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| WANG Jun.Study on the optimal formulation and preparation process of levodropropizin dropping pills by orthogonal design[J].Academic Journal of Guangdong College of Pharmacy,2010,26(1):9-12. |
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| Authors: | WANG Jun |
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| Institution: | WANG Jun (Department of Pharmacy,Renmin Hospital of Wuhan University,Wuhan,Hubei 430060,China) |
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| Abstract: | Objective To optimize the formulation and preparation process of Levodropropizin（LP） dropping pills by orthogonal design.Methods Water-soluble PEG6000 and PEG4000 were used as the main matrix with rounding and finishing degree,and weight as indices.Results The optimum was following： the matrix of PEG6000 and PEG4000（2.5∶1）,liquid paraffin as cooling solution and the ratio of drug and matrix of 1∶4,the temperature before dropping of 95 ℃,cooling solution of 10 ℃,at the dropping rate of 50 d/min and the diameter ratio of dropping tip of 1.2/1.4 mm.Conclusion This preparation of LP dropping pills was promising and deserved further study. |
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| Keywords: | levodropropizin dropping pills orthogonal design preparation process |
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