EGFR和Ki67在胃不典型增生和胃癌中的表达及二者相关性

目的：探讨表皮生长因子受体（EGFR）和Ki67在胃癌发生、发展中的作用及二者的相关性。方法：采用免疫组化双重染色法对156例正常胃粘膜、不典型增生及胃癌标本进行EGFR和Ki67染色。结果：①EGFR和Ki67在正常胃粘膜中表达均为阴性；EGFR在不典型增生、胃癌组织中表达明显高于正常胃粘膜（P＜0.01)；Ki67在胃癌中的表达率（76.6%)高于不典型增生（41.4%），有显著性意义（P＜0.01)。②EGFR表达与胃的不典型增生程度、胃癌的分化程度、组织学类型、浆膜浸润和淋巴结转移有关（P＜0.05)。③Ki67表达与胃不典型增生程度、胃癌的分化程度和组织学类型有关（P＜0.05)。⑷EGFR和Ki67表达呈显著正相关。结论：EGFR和Ki67在胃癌的发生、发展中有协同作用，可作为反映胃癌生物学行为的指标。

Expression and correlationship between EGFR and Ki67 in gastric carcinoma and precancerous lesions

Objective　To study the role of EGFR and Ki67 in the process of gastric carcinogenesis and their correlationship.Methods　Double immunohistochemical staining was used to examine the expression of EGFR and Ki67 in 156 cases of gastric specimens.Results　①Both EGFR and Ki67 were negatively expressed in normal gastric mucosa;an increased expression of EGFR was found in the gastric dysplasia and gastric carcinoma compared with normal gastric mucosa(P<0.01);the expression rate of Ki67 in gastric cancer (76.6%) were higher than that in dysplasia (41.4%)(P<0.01).②In gastric carcinoma,the expression of EGFR was related to dysplasia degree,differential degree of tumor,histological type,serosal infiltration and metastasis to lymph nodes(P<0.05).③The expression of Ki67 was related to dysplasia degree,differential degree and histological tape of tumor(P<0.05).④There was a correlation between the expression of EGFR and Ki67.Conclusion　The results suggest that EGFR and Ki67 play a cooperative role in the process of gastric carcinogenesis and may serve as a useful marker for assessment of the biological behavior of gastric carcinoma.