疱疹病毒相关性泛素特异性蛋白酶及其与肿瘤的关系

疱疹病毒相关性泛索特异性蛋白酶(HAUSP)可以分解无活性的泛素前体,保持26S蛋白酶体从泛素链上游离出来,维持细胞内足够的游离泛素水平,是泛素系统的重要调节器.最近的研究表明,HAUSP能在体内外使P53去泛素化,避免其降解,提示HAUSP可能通过稳定P53蛋白发挥肿瘤抑制功能.

Herpesvirus-associated ubiquitin-specific protease in tumor

Herpesvirus-associated ubiquitin-specific protease (HAUSP)is responsible for processing inactive ubiquitin precursors, helping to maintain a sufficient pool of free ubiquitin within the cell and for keep-ing the 26S proteasome free of ubiquitin chains. HAUSP is important regulator of the ubiquitin system. It has been recently demonstrated that HAUSP can deubiquitinate P53 both in vivo and in vitro and avoid P53 degra-dation. These results suggested that HAUSP might function as a tumor suppressor through the stabilization of P53 protein.