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| 急性白血病五种血浆凝血因子测定及临床意义 | |
| 引用本文： | 张爱华,李小亮,孙达春. 急性白血病五种血浆凝血因子测定及临床意义[J]. 现代检验医学杂志, 2003, 18(3): 51-52 |
| 作者姓名： | 张爱华 李小亮 孙达春 |
| 作者单位： | 珠海市人民医院,暨南大学医学院第三附属医院检验科,广东珠海,519000 |
| 摘 要： | 目的 探讨急性白血病(AL)血浆凝血因子V、Ⅶ、Ⅷ、Ⅸ、X活性(FV：c，FⅦ：c，FⅧ：c，FⅨ：c和FX：c)的变化。方法 采用COAG—MATE—XM型血凝自动分析仪测定36例AL患者(ANLL28例，ALL8例)五种凝血因子活性水平，并与30例正常人作对照。结果 ①AL患者FV：c，FⅦ：c，Ⅷ：c和FX：c大多降低，ANLL较ALL更显著；②组间比较：高危组FⅧ：c、FX：c降低；出血组FV：c、FⅦ：c、FⅧ：c和FX：c降低；缓解组FV：c、FⅦ：c、FⅧ：c和FX：c升高，前三项已恢复正常水平。结论 检测上述凝血因子水平对AL病情和预后判断有一定意义。 |
| 关 键 词： | 凝血因子 急性白血病 |
| 文章编号： | 1671-7414(2003)03-051-02 |
| 修稿时间： | 2002-02-19 |
Determination and Clinical Application of Five Coagulation Factors in Acute Leukemia''''s Plasma |
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| ZHANG Ai-hua,LI Xiao-liang,SUN Da-chun. Determination and Clinical Application of Five Coagulation Factors in Acute Leukemia''''s Plasma[J]. Journal of Modern Laboratory Medicine, 2003, 18(3): 51-52 | |
| Authors: | ZHANG Ai-hua LI Xiao-liang SUN Da-chun |
| Abstract: | objective To investigcte the vitality variation of five coagulation factors (F V : C, F VI : C, F VIII : C,F IX : C,F X : C)in plasma in acute leuken ia(AL). Methods Application of model COAG-MATE-XM blood coagulation automatic analysis instrument to assay the vitality of blood coagulation factors in 36 cases of acute leukemia patients (ANLL 28 cases. ALL 8 cases) which compared with 30 cases of normal person. Results (1) F V : c, FVII : c, F VIII : c and F X : c decrease in almost AL patients, and ANLL patients had a significantly lower level than ALL patients. (2)Inter-group comparison : F VIII : c,F X : c decrease in high risk group ;F V : c,FVII : c,F VIII : c and F X : c decrease in hemorrhage group ;F V : c, F VII : c,F VIII : c and F X = c increase in remission group,and ahead three item had come back to normal range. Conclusion There is some clinical significance for state and prognosis of AL by detecting that coagulation factors in blood. |
| Keywords: | coagulation factors acute leukemia (AL) |
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