Effects of Erythroid Hyperplasia on Patterns of Glycin-2-C14 Uptake in Heme and Globin of Human Peripheral Blood in Vivo期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Effects of Erythroid Hyperplasia on Patterns of Glycin-2-C14 Uptake in Heme and Globin of Human Peripheral Blood in Vivo

Authors:	NATHAN, DAVID G. GARDNER, FRANK H. Lemire, Virginia B.

Affiliation:	¹ Richard C. Curtis Hematology Laboratory, Peter Bent Brigham Hospital, andDepartment of Medicine, Harvard Medical School, Boston, Mass.

Abstract:	The rate of appearance of C¹⁴ in the heme and globin of peripheral bloodfollowing intravenous administration of glycine-2-C14 has been measured innormals and in patients with androgen-induced erythrocytosis, polycythemiavera (iron deficiency) and virilizing Cushings disease with polycythemia. Inall these cases of accelerated erythropoiesis a common alteration of the globinspecific activity curve was observed. Heme specific activity curves were notaffected. The changes in the globin specific activity curves are best explained byconsideration of the marrow erythroid cellularity during erythrocytosis. Submitted on August 6, 1965 Accepted on January 31, 1966

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