| CD28在多发性硬化患者CD8+淋巴细胞的表达 |
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| 引用本文： | 夏斌,赵忠新,张玲珍,黄坚,庄建华,邵福源.CD28在多发性硬化患者CD8+淋巴细胞的表达[J].免疫学杂志,2002,18(Z1):35-36. |
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| 作者姓名： | 夏斌 赵忠新 张玲珍 黄坚 庄建华 邵福源 |
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| 作者单位： | 1. 第二军医大学长征医院神经科,上海,200003
2. 第二军医大学长征医院实验诊断科,上海,200003 |
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| 摘 要： | 目的探讨CD28在多发性硬化(MS)患者CD8+淋巴细胞的表达水平.方法流式细胞仪测定16例复发期MS患者和20例对照组外周血淋巴细胞CD28+、CD8+CD28-和CD8+CD28+的百分率.结果复发期MS患者淋巴细胞CD8+CD28-百分率低于对照组,CD28+和CD8+CD28+的百分率与对照组无明显差异;甲基强的松龙治疗对CD28+、CD8+CD28-和CD8+CD28+的百分率无影响.结论参与MS的发病的CD8细胞是CD8+CD28-细胞.
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| 关 键 词： | 多发性硬化 抗原 CD28 抗原 CD8 |
| 文章编号： | 1000-8861(2002)03(S)-0035-02 |
| 修稿时间： | 2002年2月26日 |
Expression of CD28 on the CD8+ lymphocytes in patient with multiple sclerosis |
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| XIA Bin ,ZHAO Zhong xin ,ZHANG Ling zhen ,HUANG Jian ,ZHUANG Jian hua ,SHAO Fu yuan.Expression of CD28 on the CD8+ lymphocytes in patient with multiple sclerosis[J].Immunological Journal,2002,18(Z1):35-36. |
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| Authors: | XIA Bin ZHAO Zhong xin ZHANG Ling zhen HUANG Jian ZHUANG Jian hua SHAO Fu yuan |
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| Institution: | XIA Bin 1,ZHAO Zhong xin 1,ZHANG Ling zhen 2,HUANG Jian 1,ZHUANG Jian hua 1,SHAO Fu yuan 1 |
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| Abstract: | Objective To analyze the expression levels of CD28 on the CD8 + lymphocytes from patients with multiple sclerosis (MS).Methods The percentage of CD28 +,CD8 +CD28 - and CD8 +CD28 + were determined by flow cytometry on peripheral blood lymphocytes from 16 patients with relapsing MS and 20 controls. Results Compared to control group, the percentage of CD8 +CD28 - lymphocytes in relapses MS group decreased, the percentage of CD28 + and CD8 +CD28 + did not significantly change. Methylprednisolone treatment did not cause any significant changes of CD28 +,CD8 +CD28 - and CD8 +CD28 +. Conclusion The CD8 cell involved in MS pathogenesis were CD8 +CD28 - cell. |
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| Keywords: | multiple sclerosis antigen CD28 antigen CD8 |
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