| 氢化泼尼松和谷胱甘肽在乳腺癌化疗临床应用的观察 |
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| 引用本文： | 顾红帅,李建一,张文海,张扬,贾实,付彧.氢化泼尼松和谷胱甘肽在乳腺癌化疗临床应用的观察[J].中华肿瘤防治杂志,2010,17(2). |
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| 作者姓名： | 顾红帅 李建一 张文海 张扬 贾实 付彧 |
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| 作者单位： | 中国医科大学附属盛京医院肝胆、乳腺外科,辽宁,沈阳,110004 |
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| 摘 要： | 目的:探讨氢化泼尼松(PNS)和谷胱甘肽(GSH)在乳腺癌蒽环类化疗中对化疗毒副反应的作用。方法:接受蒽环类化疗的乳腺癌患者102例,随机分为治疗组52例和对照组50例。治疗组在常规止吐药(5-HT3受体拮抗剂-托烷司琼)的基础上予PNS和GSH静脉注射;对照组仅予止吐(5-HT3受体拮抗剂-托烷司琼)处置。观察两组患者消化道反应、骨髓抑制、心脏毒性及肝功能损害等情况。结果:在化疗中应用PNS和GSH,治疗组恶心呕吐和肝脏丙氨酸氨基转移酶(ALT)升高的发生率均显著低于对照组(P=0.03,P=0.001)。在白细胞减少和心电图改变方面,两组间数据比较差异无统计学意义,P>0.05。结论:PNS和GSH在乳腺癌蒽环类化疗中能有效地减轻化疗过程中恶心呕吐的程度、控制肝脏ALT的升高。
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| 关 键 词： | 乳腺肿瘤/药物疗法 氢化可的松 谷胱甘肽 |
Clinical observation of hydroprednisone and glutathione in chemotherapy of breast cancer |
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| GU Hong-shuai,LI Jian-yi,ZHANG Wen-hai,ZHANG Yang,JIA Shi,FU Yu.Clinical observation of hydroprednisone and glutathione in chemotherapy of breast cancer[J].Chinese Journal of Cancer Prevention and Treatment,2010,17(2). |
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| Authors: | GU Hong-shuai LI Jian-yi ZHANG Wen-hai ZHANG Yang JIA Shi FU Yu |
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| Institution: | GU+Hong-shuai,LI+Jian-yi,ZHANG+Wen-hai,ZHANG+Yang,JIA+Shi,FU+Yu+Department+of+Hepatobiliary+,+Breast+Surgery,Affiliated+Shenjing+Hospital,China+Medical+University,Shenyang,110004,P.R.China |
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| Abstract: | OBJECTIVE:To discuss whether hydroprednisone and glutathione can reduce the toxic and side effect in anthracycline chemotherapy of breast cancer.METHODS:A total of 102 patients with breast cancer accepting anthracycline chemotherapy were randomly divided into an experimental group with 52 patients and a control group with 50 patients.The patients in the experimental group were given hydroprednisone and glutathione by intravenous injection on the basis of conventional antiemetic drug(5-HT3 receptor antagonis... |
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| Keywords: | breast neoplasms/drug therapy hydroprednisone glutathione |
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