肝炎后肝硬化患者肠道菌群变化初步分析

为了研究肝炎后肝硬化与肠道菌群间的关系，对４６名肝炎后肝硬化患者和５２名健康对照者进行了对比研究。方法为取０．５克新鲜粪便，用稀释液按１０倍稀释法将粪便稀释至１０－８，然后用滴注法接种于选择性培养基。选择肠道菌群中具代表性的需氧菌和厌氧菌共１０种。结果示：（１）实验组的肠杆菌、葡萄球菌、酵母菌、拟杆菌和双歧杆菌量明显低于对照组（Ｐ＜０．０１）。（２）伴腹泻者真杆菌减少，梭菌增加（Ｐ＜０．０５）。结果表明，肝硬化患者均有不同程度的肠菌群失调，而失调的程度往往与肝功能损害程度有关。

APRELIMINARYSTUDYONTHECHANGESOF INTESTINAL MICROFLORAINPATIENTSWITHPOSTHEPATICCIRRHOSIS

n order to study the relationship between changes of posthepatic cirrhosis and intestinalmicroflora, 46 cirrhotic patients were studied with 52 healthy adults as control. Methods :Fresh fecal specimens(0.5g) were diluted serially in a decimal way to l0-8 and then inoculatedinto l0 selective culture media and selected l0 of them as representive intestinalmicroorganisms. Results:(1)The numbers of enterobacteria, staphylococci, bacteroids andbifidobacteria, were significantly less than those in controls (P< 0.01).(2)Enterobacteriadecreased and fusiformis increased in patients with diarrhea. These results showed that therewere varying degrees of changes of intestinal microflora in patients with posthepatic cirrhsis.