Interferon increases serum thrombopoietin in patients with chronic hepatitis C |
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Authors: | Goshi Shiota,Michiko Okubo,Hironaka Kawasaki,& Tomoyuki Tahara |
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Affiliation: | Second Department of Internal Medicine, Tottori University School of Medicine, Yonago; Pharmaceutical Research Laboratory, Kirin Brewery Co. Ltd, Maebashi, Japan |
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Abstract: | We measured serum thrombopoietin (TPO) in chronic hepatitis C treated with interferon (IFN). The platelet count before the therapy was 161.9 ×109 ± 64.1 × 109/l, which decreased to 116.3 × 109 ± 48.4 × 109/l 1 week after IFN therapy ( P <0.01). On the other hand, serum TPO increased from 1.96 ± 0.60 fmol/ml to 2.68 ± 0.69 fmol/ml ( P < 0.02). Contrary to a recent report that serum TPO was not altered in liver cirrhosis, these data indicate that serum TPO was increased in chronic hepatitis C in response to thrombocytopenia by IFN therapy. |
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Keywords: | thrombopoietin chronic hepatitis C interferon |
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