血必净联合糖皮质激素对三氯乙烯药疹样皮炎的疗效

目的 观察血必净注射液对三氯乙烯(trichloroethylene,TCE)药疹样皮炎并发全身炎性反应综合征(systemic inflammatory response syndrome,SIRS)的治疗效果.方法 将16例TCE药疹样皮炎并发SIRS患者随机分为血必净组(7例)与对照组(9例),对照组给予甲泼尼龙及护肝等对症支持治疗,血必净组在对照组治疗的基础上加用血必净注射液,比较两组病例甲泼尼龙初始使用剂量、总剂量、治愈时间及血清肿瘤坏死因子(TNF-α)水平.结果 两组病例均全部治愈.治疗7d后血必净组TNF-α水平(8.98±1.58)pg/ml]明显低于对照组(13.88±1.27)pg/ml],差异有统计学意义(P＜0.01).血必净治疗组甲泼尼龙使用总剂量(3882.8±223.3)mg]、治愈时间(90.3±5.9)d]均明显少于对照组甲泼尼龙使用总剂量:(4221.7±222.8)mg,治愈时间:(109.7±9.8)d],差异有统计学意义(P＜0.01).结论 血必净注射液联合糖皮质激素治疗TCE药疹样皮炎并发SIRS,可明显减少患者甲泼尼龙使用剂量,缩短糖皮质激素的使用时间.

Research of xuebijing injection combined with glucocorticoid in treating dermatitis medicamentosa like of trichioroethylene with systemic inflammatory response syndrome

Objective To study the better efficacy of clinic treatment for dermatitis medicamentosa like of trichloroethylene(DMLT)and oberserve the clinic efficacy of Xuebejing injection for DMLT patients with systemic inflammatory response syndrome(SIRS).Methods 16 DMLT patients with SIRS were randomly divided into control group(conventional therapy)and xuebijing group(conventional therapy plus xuebijing).We evaluated all the patients with APACHE Ⅱ before treatment and checked the TNF-αtin blood at the different time (before treatment and the 7th day of teatment).The total usages,first dosage of medrat and the time of therapy for each group were counted.Results All patients were cured.there was no significant difference according to APACHE Ⅱ and TNF-o before treatment in two groups.The level of TNF-αtof all the patients were decreased markedly,but more significantly in xuebijing group(P＜0.01).Moreover,the treatment group patients were given relatively less total usages、first dosage of medrat and time of therapy(P＜0.01).Conclusion Xuebejing injection combined glucocorticoids can cure DMLT patients with SIRS effictively,and reduce the total usages,first dosage of medrat and time of therapy.