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参芎葡萄糖注射液在慢性肾脏病治疗中的作用
引用本文:孙立,马健飞,朱晶,关秋实,冯江敏,王力宁. 参芎葡萄糖注射液在慢性肾脏病治疗中的作用[J]. 中国综合临床, 2012, 28(1). DOI: 10.3760/cma.j.issn.1008-6315.2012.003
作者姓名:孙立  马健飞  朱晶  关秋实  冯江敏  王力宁
作者单位:中国医科大学附属第一医院肾内科,沈阳,110001
基金项目:辽宁省自然科学基金资助项目
摘    要:目的 观察参芎葡萄糖注射液在慢性肾脏病治疗中的作用.方法 慢性肾脏病患者78例,均给予参芎葡萄糖注射液200 ml静脉滴注,1次/d,2周为1疗程,合并糖尿病患者每100 ml中加入2U胰岛素.分别测定应用参芎葡萄糖注射液治疗前、治疗后24h尿蛋白定量、血尿素氮(BUN)、肌酐(Cr)、血红蛋白(Hb)、血浆白蛋白(ALB)、红细胞比容(HCT)、纤维蛋白原(FIB)、总胆固醇(TC)、甘油三酯(TG),并进行比较.结果 应用参芎葡萄糖注射液治疗1个疗程后,患者血BUN、Cr、FIB、24h尿蛋白定量、Hb、HCT下降[(15.70±3.62)、(6.74±1.56) mmol/L,(564±65)、(189±43) μnol/L,(0.08±0.01)、(0.04±0.01 )g/L,(7.96±3.45)、(3.60±1.92)g,(83.6±10.5)、(79.5±8.7) g/L,(0.43±0.07)、(0.39±0.06)];ALB明显升高[(28.7±8.6)、(36.8±6.2)g/L],差异均有统计学意义(t值分别为3.11、2.98、3.04、2.82、2.02、2.23,P均<0.05).TC、TG较治疗前无明显变化.结论 参芎葡萄糖注射液可以改善上述患者的肾功能,减少尿蛋白排出,从而延缓慢性肾脏病的进展.

关 键 词:慢性肾脏病  参芎葡萄糖注射液  肾功能

Effect of shenxiong injection on patients with chronic kidney disease
SUN Li,MA Jian-fei,ZHU Jing,GUAN Qiu-shi,FENG Jiang-min,WANG Li-ning. Effect of shenxiong injection on patients with chronic kidney disease[J]. Clinical Medicine of China, 2012, 28(1). DOI: 10.3760/cma.j.issn.1008-6315.2012.003
Authors:SUN Li  MA Jian-fei  ZHU Jing  GUAN Qiu-shi  FENG Jiang-min  WANG Li-ning
Abstract:Objective To observe the therapeutic effects of Shenxiong glucose injection in the patients with chronic kidney diseases.Methods Seventy-eight patients with chronic kidney disease were given intravenous glucose injection 200 ml,qd,for 2 weeks.The patients who were complicated with diabetes would be given insulin 2 U/100 ml.Before and after Shenxiong injection treatment,24 h urinary protein,blood urea nitrogen ( BUN),creatinine ( Cr),hemoglobin ( Hb),albumin ( ALB),hematocrit ( HCT),fiber fibrinogen (FIB),cholesterol (TC) and triglyceride (TG) were measured and compared.Results After 1 course of Shenxiong treatment,the serum BUN,Cr,FIB,24 h urinary protein,Hb and HCT ( [ 15.70 ± 3.62 ] mmol/L vs.[6.74 ± 1.56 ] mmol/L,[ 564 ± 65 ] μmol/Lvs.[ 189 ± 43 ] μmol/L,[ 0.08 ± 0.01 ] g/L vs.[ 0.04 ± 0.01 ] g/L,[7.96 ±3.45]g vs.[3.60 ± 1.92]g,[83.6 ±10.5]g/L vs.[79.5 ±8.7]g/L,[0.43 ±0.0] vs.[0.39 ±0.06 ] were decreased,and ALB ( 28.7 ± 8.6) vs.( 36.8 ± 6.2) was increased.The difference was statistically significant (t =3.1 1,2.98,3.04,2.82,2.02,2.23,P<0.01 for all).TC and TG were not changed much after the treatment.Conclusion Shenxiong injection can improve the kidney function,lower Fibrinogen and urine protein,which may effectively slow down the progress of chronic kidney disease and improve the life quality.
Keywords:Chronic kidney disease  Shenxiong injection  Kidney function
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