维药驱虫斑鸠菊化学成分、质量控制及其药理活性的研究进展

维药驱虫斑鸠菊为菊科斑鸠菊属植物驱虫斑鸠菊(Vernonia anthelmintica Willd.)的干燥成熟种子,是维吾尔族常用药材,主产于中国新疆和巴基斯坦等地。由于其对于白癜风等皮肤病的治疗有独特的疗效,近年来受到越来越多的关注。驱虫斑鸠菊中主要化学成分为倍半萜及其二聚体、黄酮、甾体等类成分。由于产地独特的地理环境和气候,形成了较为独特的化学成分,倍半萜类成分主要为榄香烷型,该类型倍半萜在菊科其他属中较为少见;并且大多数分离得到的倍半萜在8位上连接有较为少见的2-(羟甲基)丙烯酰基。驱虫斑鸠菊的质量控制及药理活性也有报道。本文对驱虫斑鸠菊的化学成分、质量控制及药理活性进行系统归纳整理,以期为该药材的开发利用提供参考。

Research progress on phytochemical,quality control and pharmacological effects of Uyghur medicine Fructus Vernoniae

Fructus Vernoniae is dry mature seeds of Vernonia anthelmintica Willd. belonging to Compositae. It is frequently used as medicinal herbs in the Uyghur medicines and is mainly produced in Xinjiang Uygur aotonomous region and Pakistan. Due to its unique curative effect on the treatment of skin diseases such as vitiligo,it has received more and more attention in recent years. The main chemical constituents of V. anthelmintica are sesquiterpenoids and their dimers,flavonoids and steroids. Due to the unique geographical environment and climate of the place of origin,relatively unique chemical constituents were produced. Most sesquiterpenoids are elemanolides,which are rare in othergenus of Compositae. And a relatively rare 2-(hydroxymethyl) acryloyl group is attached to 8-position of elemanolide. There were also many reports on quality control and pharmacological activities of V. anthelmintica. This paper summarized chemical constituents,quality control and pharmacological activities of this herb with expectation to provide valuable reference for development and utilization of this herb.