注射用双黄连治疗小儿病毒性心肌炎疗效观察

探讨病毒性心肌炎患儿免疫功能状态及双黄连的干预作用。方法：用ＥＬＩＳＡ及间接免疫荧光法测定了６２例心肌炎患儿血清中柯萨奇Ｂ组病毒抗体及Ｔ细胞亚群ＣＤ＾＋３，ＣＤ＾＋４，ＣＤ＾＋８，ＣＤ＾＋４／ＣＤ＾＋８，工将其随机分成两组：双黄连组及常规组。

Clinical Study on Shuanghuanglian Powder in Treating Children Viral Myocarditis

Objective: To study immune function of children viral myocarditis and to evaluate the clinical effect of Shuanghuanglian Powder (SHLP). Methods: The authors determined serum COXB IgM and the numbers of lymphocyte subsets CD 3, CD 4, CD 8, CD 4/CD 8 with viral myocarditis patients by ELISA and indirect immunofluorescent assay. Sixty two cases were divided randomly into two groups. Thirty two cases treated by conventional therapy with SHLP and the other 30 cases treated with conventional therapy alone were taken as control group. Results: COXB IgM was positive in 39 of 62 patients, which were significantly different with those of normal controls (P<0 001). In addition, the level of CD 4 cells and the ratio of CD 4/CD 8 were decreased while CD 8 increased. After treatment with SHLP, the recovery of symptoms, signs and immune function in patients were better than that of controls. These changes were significantly different (P<0 01). Conclusions: There were disturbance of immune regulatory function with children viral myocarditis patients and SHLP is an effective drug in treating children viral myocarditis.