人上颌窦鳞癌及粘膜不典型增生组织中表皮生长因子受体的表达

目的 :探讨表皮生长因子受体 (EGFR)在上颌窦鳞癌发生不同阶段中的表达情况。方法 :应用免疫组织化学LSAB法 ,分别观测EGFR在上颌窦正常粘膜、慢性炎症及鳞癌组织中的表达情况 ,以及其与上颌窦鳞癌临床病理学特征间的关系。结果 :EGFR在上颌窦不典型增生粘膜和鳞癌中的阳性表达率明显高于正常、单纯增生的粘膜 ,鳞癌组织中的表达又明显高于不典型增生组织 (P <0 0 5 ) ;EGFR的阳性表达与患者的性别、年龄、肿瘤组织的分化程度无关 (P >0 0 5 ) ,而与患者的淋巴结转移与否及 3a生存期有关 (P <0 0 5 )。结论 :EGFR在上颌窦鳞癌发生发展中起重要作用 ,可作为判断上颌窦鳞癌生物学行为和预后的一个参考指标。

Expressions of EGFR in human maxillary sinus squamous cell carcinoma and dysplasia of epithelial tissue

Aim:To assess the changes and possible role of expression of EGFR in maxillary sinus carcinogenesis.Methods:Immunohistochemical LSAB.Results:The positivity rates of EGFR in maxillary sinus dysplasia and squamous cell carcinoma of the epithelia were significantly higher than those in normal and simple hyperplastic epithelia,and that of EGFR in squamous cell carcinoma was significantly higher than that in dysplasic epithelia ( P <0 05).The expressions of EGFR did not correlate with sex,age,and histologic grade ( P >0 05),but significantly correlated with lymph node metastasis and the survival stage (3 a)( P <0 05).Conclusion: The incresed expression of EGFR may play an important role in the process of carcinogenesis in mxillary sinus squamous cells and can be used as a useful marker for the assessment of biological behavior and prognosis of maxillary sinus squamous cell carcinoma.