| 应力状态下软骨基质分解代谢的变化 |
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| 引用本文： | 邵越峰,卫小春.应力状态下软骨基质分解代谢的变化[J].中国骨伤,2009,22(3):241-244. |
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| 作者姓名： | 邵越峰 卫小春 |
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| 作者单位： | 山西医科大学第二医院骨科,山西,太原,030001 |
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| 基金项目： | 山西省归国留学人员重点科研项目 |
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| 摘 要： | 骨关节炎（osteoarthritis，OA）是力学和生物学因素共同作用下导致软骨细胞、细胞外基质以及软骨下骨三者降解和合成正常偶联失衡的结果。OA发病过程中生物力学因素的异常，导致MMPs／TIMPs的失衡，是OA发病的中心环节。因此本文就应力状态下软骨基质分解代谢的变化作一综述。
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| 关 键 词： | 骨关节炎 应力 物理 软骨 分解代谢 |
| 收稿时间： | 2008/6/25 0:00:00 |
Change of cartilage matrix metabolism under stress |
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| SHAO Yue-feng and WEI Xiao-chun.Change of cartilage matrix metabolism under stress[J].China Journal of Orthopaedics and Traumatology,2009,22(3):241-244. |
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| Authors: | SHAO Yue-feng and WEI Xiao-chun |
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| Institution: | Department of Orthopaedics,the Second Affiliated Hospital,Shanxi Medical University,Taiyuan 030001,Shanxi,China;Department of Orthopaedics,the Second Affiliated Hospital,Shanxi Medical University,Taiyuan 030001,Shanxi,China |
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| Abstract: | With the effects of the mechanics and biological factors,the imbalance between the degradation and synthesis of chondrocyte,extracelluar matrix and subchondral bone leads to the osteoarthritis. The imbalance between MMPs and TIMPs caused by biomechanical abnormality is the key factor of osteoarthritis. This review will focus on the stress and their roles in the metabolism of the cartilage matrix. |
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| Keywords: | Osteoarthritis Stress mechanical Cartilage Metabolism |
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