Histopathology of colorectal carcinomas and adenomas in cancer family syndrome |
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Authors: | Jukka-Pekka Mecklin MD Pentti Sipponen MD Dr Heikki J Järvinen MD |
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Institution: | (1) Second Department of Surgery, Helsinki University Central Hospital, 00290 Helsinki, Finland;(2) Department of Pathology, Jorvi Hospital, Espoo |
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Abstract: | Seventy-five colorectal carcinoma patients (100 separate cancers) with verified cancer family syndrome were re-examined for
the evaluation of histologic characteristics in carcinomas and adenomatous polyps in this inherited syndrome in a comparison
with control patients with colorectal carcinoma but no hereditary background. In the cancer family syndrome group there were
significantly more mucinous carcinomas (35 to 39 percent vs. 20 percent;P<0.05–0.01), and also more poorly differentiated tumors (24 vs. 12 percent) than in the control group. The differences could
not be explained by the site or stage of the tumors or by the age or sex of the patients. Additional adenomas occurred quite
often both in cancer family syndrome patients (19 percent) and in the controls (16 percent). In the cancer family syndrome
group, however, there were more adenomas with moderate or severe dysplasia (P<0.01) and more adenomas with villous features (P<0.05) than in the control group. Mucinous histologic features in colorectal carcinoma, although not fully specific, might
be characteristic of cancer family syndrome, and thus serve as one sign in the indentification of the syndrome. The presence
of the adenoma-carcinoma sequence in cancer family syndrome also was supported, and the histologic aggressivity of the associated
adenomas might signify an accelerated advancement of this phenomenon in cancer family syndrome.
Supported by the Finnish Cancer Foundation. |
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Keywords: | Mucinous colorectal carcinoma Cancer family syndrome Adenoma-carcinoma sequence |
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