乳腺浸润性癌PS2蛋白的表达及其与预后的关系

目的探讨ＰＳ２蛋白在乳腺浸润性癌中的表达及其与预后的关系。方法应用ＬＳＡＢ免疫组化法检测ＰＳ２蛋白在８６例乳腺浸润性癌中的表达。结果ＰＳ２蛋白的表达率为６６．２７％（５７／８６）。在下列一些情况中，ＰＳ２蛋白的表达率有区别：（１）８６例中，５年以上组８０．５５％（２９／３６），５年以下组５６．００％（２８／５０），差异有显著性意义（Ｐ＜０．０２５）；（２）未停经组６２例，５年以上组８６．２０（２５／２９），５年以下组５４．５４％（１８／３３），差异有显著性意义（Ｐ＜０．００５），已停经组２４例，５年以上组４／７例，５年以下组５８．８０％（１０／１７），差异无显著性意义；（３）腋窝淋巴结转移６２例，５年以上组８２．３５％（１４／１７），５年以下组５５．５５％（２５／４５），差异有显著性意义（Ｐ＜０．０５）；腋窝淋巴结阴性２４例，５年以上组７８．９４％（１５／１９），５年以内组３／５例，差异无显著性意义。结论本研究表明，ＰＳ２蛋白的阳性表达与５年生存期正相关，ＰＳ２阳性的表达可以作为乳腺癌的一项预后指标；ＰＳ２蛋白表达对未停经患者的内分泌治疗具有一定的指导意义；腋窝淋巴结阳性患者ＰＳ２蛋白表达与较好的预后相关。

Study on the relationship between PS2 protein expression and prognosis in invasive breast carcinoma

OBJECTIVE: To study the relationship between the expression of PS2 protein and prognosis in the invasive breast cancer (IBC). METHOD: Using LSAB immunohistochemical method, PS2 protein expression in 86 cases of IBC was detected. RESULTS: The positive rate of PS2 protein was 66.27% (57/86) in 86 cases of IBC. Under the following 3 conditions, PS2 protein expression levels in the more-than-5-year-survival group (A) were higher than those in the less-than-5-year-survival group (B). (1) In 86 cases of IBC, the expression level was 80.55% (29/36) for Group A, Significantly different from the 56.00% (28/50) of Group B (P < 0.025). (2) In 62 cases of premenopausal patients, the corresponding data were 86.20% (25/29) and 54.54% (18/33) respectively, P < 0.005; whereas in 24 cases of postmenopausal patients, 4/7 and 58.82% (10/17) respectively, P > 0.5. (3) In 62 cases of axillary node positive patients, the expression levels for Groups A and B were 82.35% (14/17) and 55.55% (25/45) respectively, P < 0.05; while in 24 cases of axillary node negative patients, 78.94% (15/19) and (3/5) respectively, P > 0.5. CONCLUSIONS: These results suggest that the expression of PS2 protein was positively correlated with 5-year-survival in IBC, and could be considered as a prognostic predictor for breast cancer, PS2 protein expression was a useful indicator for endocrine therapy in premenopausal patients. In axillary node positive patients, the expression of PS2 protein was associated with a better prognosis.