外阴血管肌纤维母细胞瘤的临床病理及鉴别诊断

目的 探讨血管肌纤维母细胞瘤(AMF)的临床病理特征及鉴别诊断。方法通过4例AMF的病理形态和免疫组化研究，结合复习文献，总结AMF的临床病理特征及鉴别诊断。结果肿瘤境界清楚，瘤细胞梭形或卵圆形，常围绕血管排列，呈疏密交替分布特征。免疫组化表型：瘤细胞Vimendn(4／4)、Acfin(2／4)、SMA(2／4)、CD34(2／4)、ER(2／4)、PR(2／4)阳性，Desmin、S-100、Ck均阴性。结论AMF是一种主要发生于生育期女性外阴的良性软组织肿瘤，需与侵袭性血管粘液瘤、浅表性血管粘液瘤、富细胞性血管纤维瘤等鉴别。

Clinicopathological Features and Differential Diagnosis of Vulval Angiomyofibroblastoma

Purpose To study the clinicopathological characteristics of angiomyofibroblastoma(AMF) and its differential diagnosis.Methods The clinicopathological features and the differential diagnosis were studied through histopathological and immunohistochemical staining of 4 cases of AMF and literatures review.Results Tumors were all well circumscribed,characterized by alternating hypercelluar and hypocellur edematous zones with numerous blood vessels.Plump spindled or oval cells were aggregated around the blood vessels.Immunohistochemically,the tumor cells were reactive for Vimentin,Actin,SMA,CD34,ER,PR,but not Desmin,S-100 protein and CK.Conclusions AMF is a benign soft tissue tumor that occurs principally in the vulval region of reproductive-age woman.It needs to make differential diagnoses with several tumors usually occurring in this area,such as aggressive angiomyxoma,superficial angiomyxoma and celluar angiofibroma.