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| 曲司氯铵的合成 | |
| 引用本文： | 刘素云. 曲司氯铵的合成[J]. 中国医药工业杂志, 2010, 41(3) |
| 作者姓名： | 刘素云 |
| 作者单位： | 北京科莱博医药开发有限责任公司,北京,102600 |
| 摘 要： | 二苯基羟乙酸与1,1'-羰基二咪唑反应生成二苯基羟乙酰咪唑,再与莨菪醇成酯、脱甲基、环合成季铵盐,制得毒蕈碱受体拮抗剂曲司氯铵,总收率约19%. |
| 关 键 词： | 曲司氯铵 毒蕈碱受体拮抗剂 尿失禁 膀胱过动症 合成 |
Synthesis of Trospium Chloride |
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| LIU Suyun. Synthesis of Trospium Chloride[J]. , 2010, 41(3) | |
| Authors: | LIU Suyun |
| Abstract: | Trospium chloride was prepared from 2-hydroxy-2,2-diphenylacetic acid by activation with CDI, esterfication with tropine, demethylation and cyclization. The overall yield was about 19%. |
| Keywords: | trospium chloride muscarinic receptor antagonist anischuria overactive bladder synthesis |
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