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Case Report: Interferon induced coma in Sheehan's syndrome
Authors:KATSUHIRO MABE  HARUHIDE SHINZAWA    KEIICHI YAMATANI  TADASHI TAKEDA  MASAMICHI ISHIBASHI  NOBUO YAMADA  HIROYUKI MISAWA  HIROTO WAKABAYASHI  HITOSHI TOGASHI  TSUNEO TAKAHASHI
Affiliation:Second Department of Internal Medicine, Yamagata University School of Medicine, Yamagata, Japan;*Third Department of Internal Medicine, Yamagata University School of Medicine, Yamagata, Japan
Abstract:
A 54-year-old woman who was being treated with 10 million units (mu) of natural interferon (IFN)-α per day for chronic active hepatitis C at a local clinic, developed coma on the fourth day of treatment. On admission to Yamagata University Hospital, she was still in a state of semicoma with severe hyponatraemia (122 mEq/L) and hypochloraemia (89 mEq/L). After the administration of electrolytes, her condition improved remarkably. Endocrinological loading tests showed a hypofunction of the anterior pituitary gland. In consideration of these results, and her past experiences of haemorrhage during childbirth and subsequent amenorrhoea, we diagnosed her illness as a coma as a result of Sheehan's syndrome which had become overt during IFN therapy. She recovered completely after treatment with hydrocortisone and 1-thyroxine.
Keywords:chronic hepatitis C,    coma,    interferon therapy,    Sheehan's syndrome.
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