| 浙江畲族DYS287、DYS440位点的多态性研究 |
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| 引用本文： | 闫春兰,詹金彪,邵靖宇.浙江畲族DYS287、DYS440位点的多态性研究[J].中华医学遗传学杂志,2004,21(4):410-411. |
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| 作者姓名： | 闫春兰 詹金彪 邵靖宇 |
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| 作者单位： | 310031,杭州,浙江大学医学院生物化学与分子生物学教研室 |
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| 基金项目： | 浙江大学医学院青年启动基金 (540 1 2 3)~~ |
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| 摘 要： | 目的 研究浙江畲族人群中DYS2 87和DYS44 0位点的多态性。方法 采用聚合酶链反应扩增DYS2 87和DYS44 0 ,PCR产物用 2 %的琼脂糖电泳分析 10 0名畲族个体的基因型。结果 10 0名个体DYS2 87位点全部是YAP-;没有发现YAP ;10名为DYS44 0 3 ,占总人群数的 10 % ,其余 90名是DYS44 0 4。结论 浙江畲族人群DYS2 87和DYS44 0多态性与属于汉藏语系的其它民族之间存在着明显的不同 ,因此这两个基因位点对研究人类的进化是一种稳定的、重要的遗传标记。
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| 关 键 词： | DYS287位点 DYS440位点 遗传多态性 Y染色体 |
| 修稿时间： | 2003年9月4日 |
Polymorphic analysis of DYS287 and DYS440 in She ethnic in Zhejiang province China |
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| YAN Chun-lan,ZHAN Jin-biao,SHAO Jing-yu..Polymorphic analysis of DYS287 and DYS440 in She ethnic in Zhejiang province China[J].Chinese Journal of Medical Genetics,2004,21(4):410-411. |
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| Authors: | YAN Chun-lan ZHAN Jin-biao SHAO Jing-yu |
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| Institution: | Department of Biochemistry and Molecular Biology, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, 310031 PR China. Clyan@hzcnc.com |
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| Abstract: | Objective To study the polymorphisms of DYS287 and DYS440 in Zhejiang She population. Methods Detection of DYS287 and DYS440 polymorphisms was performed in 100 She individuals by using polymerase chain reaction amplification and 2% agarose gel electrophoresis. Results With 150 bp product in all She individuals, YAP was absent. DYS440*3 was present in 10 She individuals (10%); DYS440*4 was present in the other 90 She individuals(90%). Conclusion The polymorphisms of DYS287 and DYS440 in Zhejiang She population were different from those in the other populations that belong to Sino-Tibetan Language Family. So both DYS440 and DYS287 are important and stable genetic markers, they can provide reliable evidence in human evolution study. |
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| Keywords: | DYS287 DYS440 genetic polymorphism Y chromosome |
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