Nodal T-cell lymphomas with a T-follicular helper cell phenotype |
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Affiliation: | 1. Institute of Pathology, University Hospital, 91054 Erlangen, Germany;2. Department of Pathology, Faculty of Medicine in Pilsen, Charles University, 30460 Plzen, Prague;3. Biomedical Center, Faculty of Medicine in Pilsen, Charles University, 30460 Plzen, Czech Republic;4. Department of Pathology, First Faculty of Medicine, Charles University in Prague, 100 00 Prague, Czech Republic |
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Abstract: | The discovery and characterisation of T-follicular helper (TFH) cells, a distinct functional subset of T-helper cells has led to the recognition that some peripheral T-cell lymphomas (PTCLs) have a TFH cell immunophenotype. Due to the overlap in clinical, morphological, immunophenotypic and genetic characteristics, the revised 4th edition to the WHO classification recognises one umbrella category of ‘angioimmunoblastic T-cell lymphoma and other nodal TCLs of TFH cell origin’. This review provides a brief overview of TFH cells with special emphasis on function and phenotype and a more detailed discussion of clinical, morphologic, immunophenotypic and genotypic characteristics of AITL, follicular T-cell lymphoma and nodal PTCL with TFH phenotype which constitute nodal TCLs of TFH origin. Secondary B-cell proliferations (often EBV positive) and features that help differentiate reactive lymphoid hyperplasia and other types of lymphoma, including PTCL, NOS and secondary B-cell lymphomas and classic Hodgkin lymphoma, from nodal TCLs with a TFH phenotype are discussed. |
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Keywords: | angioimmunoblastic follicular T-cell lymphoma T-follicular helper cell |
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