激素替代治疗对绝经后妇女血清补体和免疫球蛋白水平的影响

目的：探讨激素替代治疗（HRT）对绝经后妇女血清补体C3、C4和免疫球蛋白IgG、IgM水平的影响。方法：将108例绝经妇女随机分为两组，HRT组：服用倍美力0．625mg＋安宫黄体酮2．5mg／d，共6个月；对照组：不服用任何激素类药物。于治疗结束后检测妇女血清补体C3、C4和免疫球蛋白IgG、IgM水平。结果：HRT组妇女血清补体C3、C4水平较对照组明显升高（P〈0．01），两组血清免疫球蛋白IgG、IgM无显著差异。结论：炎症反应因子补体C3、C4水平升高可能是绝经后妇女应用HRT后心血管疾病发生率增加的原因之一。

Effect of Hormone Replacement Therapy on Serum Complement (C3, C4) and Immunoglobulin (IgG, IgM) Levels in Post-menopausal Women

Objective: To evaluate the effect of hormone replacement therapy(HRT) on serum complement and immunoglobulin levels in post-menopausal women. Methods: 108 cases healthy post-menopausal women were divided into two groups: 54 women received CEE 0. 625 mg + MPA2. 5mg per day for six months(HRT group), 54 women not receiving any therapy (Controls group). The serum C3, C4, IgG and IgM levels were assessed in each group. Results; The mean serum C3 and C4 level was significantly higher in HRT group than those in the control group(P< 0. 01 ). IgG and IgM levels were similar between two groups. Conclusion; It is concluded that HRT may be involved in the development of cardiovascular disease through inflammatory mechanisms, as suggested by increased serum levels of C3 and C4.