| 新型消化性溃疡治疗药拉呋替丁 |
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| 引用本文： | 陈伟强,许德义.新型消化性溃疡治疗药拉呋替丁[J].中国新药与临床杂志,2003,22(4):247-250. |
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| 作者姓名： | 陈伟强 许德义 |
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| 作者单位： | 东南大学基础医学院,药理学教研室,江苏,南京,210009 |
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| 摘 要： | 拉呋替丁是一种新型非竞争性组胺H2 受体拮抗药 ,通过阻断组胺H2 受体和辣椒素感受神经减少胃酸分泌、促进胃粘膜再生、增加胃粘膜血流量以及增加胃粘液等机制发挥抗消化性溃疡作用。同其他组胺H2 受体拮抗药相比 ,本品具有疗效显著、不良反应少和治愈后不易复发等优点
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| 关 键 词： | 拉呋替丁 组胺H2受体拮抗药 消化性溃疡 药理学 毒理学 临床试验 |
| 文章编号： | 1007-7669(2003)04-0247-04 |
Lafutidine, a novel antiulcer drug |
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| CHEN Wei qiang,XU De yi.Lafutidine, a novel antiulcer drug[J].Chinese Journal of New Drugs and Clinical Remedies,2003,22(4):247-250. |
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| Authors: | CHEN Wei qiang XU De yi |
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| Abstract: | Lafutidine is a novel antiulcer drug with potent antisecretory and gastroprotective activities. The antisecretory effect is based on histamine H 2 receptor antagonism. Through the mechanisms of capsicin sensitive nerves, lafutidine also has stimulatory effect on gastric mucus biosynthesis, and increasing the gastric mucosal blood flow. Contrast to other H 2 receptor antagonism, such as famotidine and cimetidine, the potency of lafutidine for various ulcers is greater. Lafutidine has the properties of obvious therapy effect, less adverse reactions and less relapse when cared. |
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| Keywords: | lafutidine histamine H 2 receptor blockaders peptic ulcer pharmacology toxicology clinical trials |
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