结肠癌中多药耐药相关蛋白和肺耐药蛋白的表达

目的:探讨结肠癌中多药耐药相关蛋白(MRP)和肺耐药蛋白(LRP)的表达及意义。方法:采用免疫组化法检测51例结肠癌和32例癌旁相对正常结肠中MRP和LRP的表达情况。结果:51例结肠癌中MRP的阳性率为41.18％(21/51),32例癌旁相对正常结肠中MRP的阳性率为18.75％(6/32),两组比较差异有显著性(P<0.05)。LRP的表达与结肠腺癌的分化程度相关,高分化腺癌的阳性率为90.00％(9/10),中分化腺癌的阳性率为79.66％(23/29),高于低分化腺癌20.00％(1/5)的阳性率,差异有显著性(P<0.05)。结肠癌中MRP与LRP的表达存在相关性(P<0.05)。结论:结肠癌中MRP和LRP均为高表达,两者均可能是结肠癌原发性多药耐药的重要机制,且两者可能有协同作用。临床上检测这2种蛋白的表达,有助于对化疗药物的选择。

Expression of the Multidrug Resistance-associated Protein and Lung Resistance Protein in Human Colon Carcinoma and Its Clinical Significance

Objective: To detect the expression of multidrug resistance-associated protein (MRP) and lung resistance protein (LRP) in human colon carcinomas and its significance. Methods: The ex-pression of MRP and LRP in 51 cases of colon carcinomas and 32 cases of adjacent relative normai colon tissue were examined with immunohistochemical staining. Results: The positive expression rate of MRP in 51 cases of colon carcinomas was 41. 18% (21/51) , and that in 32 cases of adjacent relative normai colon tissue was 18. 75% (6/32). The difference was notable (P <0. 05). The expression of LRP was closelv correlated with the differentiation degree of the colon adenocarcinoma. Its positive rate in well differentiated adenocarcinoma was 90. 00% (9/10) , in moderatelv differentiated adenocarcinoma 79. 66% (23/29) , and both were higher than that in poorly differentiated adenocarcinoma 20. 00% (1/5). The difference was significant ( P < 0. 05). The expression of MRP and LRP in colon carcinomas was correlated (P < 0. 05). Conclusions: MRP and LRP highly express in colon carcino-ma, and both of them may be one of the important mechanisms of intrinsic multidrug resistance ( MDR) and play a co-operative part in colon carcinomas. The examination of them can help to choose more effective chemotherapy drugs.