Normal and myopathic propagation of surface motor unit action potentials |
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| Authors: | P Hilfiker M Meyer |
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| Affiliation: | 1. Institute of Biomedical Engineering, ETH and University of Zurich, Moussonstrasse 18, 8044 Zurich, Switzerland;2. Department of Neurobiology, University Hospital Zurich, Raemistrasse 100, 8091 Zurich Switzerland;1. ECOFISTEM Research Group, Health Sciences Department, Facultad de Ciencias de la Salud, Universidad Católica de Murcia, Guadalupe, Murcia, Spain;2. Centro Universitario de Ciencias de la Salud San Rafael-Nebrija, Madrid, Spain;3. Department of Neurology, Hospital Universitario y Politécnico La Fe, Valencia, Spain;4. Neuromuscular and Ataxias Research Unit, Instituto de Investigación Sanitaria la Fe (IIS La Fe), Valencia, Spain;5. Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Valencia, Spain;6. Physiotherapy Department, Facultad de Medicina, Universidad de Murcia, Murcia, Spain;1. Department of Neurology, The Johns Hopkins Hospital, Baltimore, MD, United States;2. Department of Neurology, Tawam Hospital, Al Ain, United Arab Emirates;3. Department of Neuroradiology, Johns Hopkins Hospital, Baltimore, MD, United States;4. Unit of Radiology, Hospital “S.Maria del Carmine” (APSS), Rovereto, Italy;5. Division of Clinical Genetics and Metabolic Disorders, Department of Pediatrics, Tawam Hospital, Al-Ain, United Arab Emirates;6. Department of Neurology, Rutgers University, NJ, United States;1. University of Groningen, University Medical Center Groningen, Center for Human Movement Sciences, Sector F, FA23, P.O. Box 196, 9700 AD Groningen, The Netherlands;2. University of Groningen, University Medical Center Groningen, Department of Rehabilitation Medicine, PO Box 30.001, 9700 RB Groningen, The Netherlands;1. Department of Neurology, Brain Centre Rudolf Magnus, University Medical Centre Utrecht, Utrecht University, Utrecht, Netherlands;2. Institute for Risk Assessment Sciences, Utrecht University, Utrecht, Netherlands;1. Oxford Centre for Clinical Magnetic Resonance Research (OCMR), Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK;2. Axcella Therapeutics, Cambridge, MA, USA;3. University College London, London, UK;4. Oxford NIHR Biomedical Research Centre, Oxford University Hospitals Foundation Trust, Oxford, UK;5. Institute of Measurement Science, Slovak Academy of Sciences, Bratislava, Slovakia |
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| Abstract: | ![]()
With the aid of a computer-assisted multichannel EMG system, the propagation of motor unit action potentials is analysed during isometric voluntary muscular contraction under normal and myopathic conditions. A linear array of 30 surface electrodes is fixed above the biceps brachii muscle, parallel to the longitudinal muscle axis and centered over the end-plate zone. The EMG is simultaneously recorded on all channels and displays the propagation of surface potentials on both sides of the innervation band. The mean muscle fibre conduction velocity is computed by a cross-correlation technique. Five adult patients in a late stage of progressive muscular dystrophy show a highly altered propagation behaviour of motor unit action potentials without a time shift between potentials of adjacent electrodes. A mathematical model is described which predicts such a behaviour and suggests that it must be due to a pathological longitudinal spread of end-plates in this patient group. In 5 boys with Duchenne muscular dystrophy and only moderate impairment of the biceps muscle the mean muscle fibre velocity was reduced (2.81 +/- 0.34 m/sec) compared to 17 healthy subjects (4.42 +/- 0.37 m/sec). Each myopathic patient examined could be separated clearly from the group of healthy subjects on the basis of the surface EMG analysis. |
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