重型乙型肝炎病人聚人血清白蛋白受体的研究

采用放射免疫分析法,对33例重型乙肝(SH)(亚急性8例:SSH;慢性25例:CSH及13例急性乙肝(AH)、23例慢活乙肝(CAH)、10例无症状HBsAg携带者(ASC)和28个正常人的血清检测了聚人血清白蛋白受体(PHSA-Re),并同时对照观察了HBV的其它几项相关血清学指标。PHSA-Re在SH病人血清中的阳性率与AH、CAH和ASC组病人血清中阳性率无明显差别,但阳性P/N值明显低于CAH组(P<0.05)和ASC组(P<0.01)。说明PHSA-Re在SH病人血清中的存在状态不同于ASC和CAH病人,PHSA-Re与HBeAg、HBV-DNA有明显的相关性,但PHSA-Re与重型乙肝病人预后的关系尚待明确。

A Study of Polymerized Human Serum Albumin Receptor in the Serum of Patients with Severe Hepatitis B

The sera from 33 patients with severe hepatitis B (SH) ( 8 subacute and 25 chronic cases), 13 patients with acute hepatitis (AH), 23 patients with chronic active hepatitis B (CAH), 10 HBsAg asymptomatic carriers (ASC), and 28 normal persons were tested with RIA to detect the polymerized human serum albumin receptor (PHSA-Re). Some related parameters of HBV were tested simultaneously in order to have a comparison.There was no significant difference of the positive rate of PHSA-Re between the patients with SH and those with AH, CAH, or ASC. But the difference of positive P/N ratio between SH patients and those with CAH(P< 0.05) or ASC (P<0.01) was statistically significant. This result suggests that the existence of PHSA-Re in the serum of SH patients may not be in the same condition as that of CAH or ASC patients. The correlation between PHSA-Re and HBsAg and HBV-DNA is obvious, but the relationship between PHSA-Re and the prognostic assessment of SH patients awaits further clerification.