左氧氟沙星与头孢呋辛联合阿奇霉素治疗社区获得性肺炎疗效对比

目的 对比单用左氧氟沙星与头孢呋辛联合阿奇霉素治疗社区获得性肺炎的临床疗效、细菌清除率和安全性.方法 将75例社区获得性肺炎患者按随机数字表法分为左氧氟沙星治疗组(40例)和对照组(头孢呋辛联合阿奇霉素组,35例),观察两组患者临床疗效、细菌清除率和不良反应.结果 左氧氟沙星组40例,痊愈33例(82.5%),显效4例(10.0%),总有效率为92.5%,细菌清除率为94.7%,不良反应发生率为2.5%;对照组35例,痊愈28例(80.0%),显效4例(11.4%),总有效率为91.4%,细菌清除率为92.3%,不良反应发生率为2.9%.两组临床疗效、细菌清除率、不良反应发生率间差异均无统计学意义(P＞0.05).结论 左氧氟沙星组的给药方法为1次/d大剂量,患者的依从性好于2次/d给药的头孢呋辛联合阿奇霉素组,患者耐受性良好,不良反应发生率不高.这一用药方案的应用,将进一步拓展左氧氟沙星在治疗社区获得性肺炎中的作用.

A Comparison between Levofloxacin and Cefuroxime with Azithromycin in Community-acquired Pneumonia

Objective To compare the clinical effects,bacterium clearances and safety of levofloxacin and cefuroxime with azithromycin in treatment of community-acquired pneumonia(CAP).Methods Seventy-five CAP patients were randomly divided into groups levofloxacin(therapy group,n=40) and cefuroxime plus azithromycin(control group,n=35),to observe the efficacy,pathogen clearance rates and side effects.Results In therapy group,33 were clinical cured(82.5%),4 improved(10.0%),and the total effective rate,bacterium clearance and adverse reaction incidence were 92.5%,94.7%,2.5%,respectively.In control group,28 cured(80.0%),4 improved(11.4%),and the total effective rate,bacterium clearance and adverse reaction incidence were 91.4%,92.3%,2.9%,respectively,there were no significant differences between two groups(P＞0.05).Conclusion Medication of treatment group is given once/d,in a large dose,and the patients′ compliance is better than that of control (twice/d),with good tolerability and low incidence of adverse reactions.This medication will further expand the application of levofloxacin in CAP treatment.