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| 2型糖尿病血清瘦素质量浓度与胰岛素抵抗的关系 | |
| 引用本文： | 周亚茹,王战建,庞建华,张耀. 2型糖尿病血清瘦素质量浓度与胰岛素抵抗的关系[J]. 中国实用内科杂志, 2005, 25(11): 992-993 |
| 作者姓名： | 周亚茹 王战建 庞建华 张耀 |
| 作者单位： | 河北医科大学第三医院内分泌科,石家庄,050051 |
| 摘 要： | 目的探讨2型糖尿病人群血清瘦素水平与胰岛素抵抗的关系。方法2001-102002-08对河北医科大学第三医院的196例受试者(2型糖尿病者118例、对照者78名)用放射免疫法测定空腹血清瘦素水平,同时测量身高、体重、腰围、臀围。结果糖化血红蛋白(HbA1c)、收缩压(SBP)、甘油三酯(TG)和瘦素(Leptin)是影响胰岛素敏感性的因素;2型糖尿病组瘦素质量浓度高于对照组;肥胖者瘦素质量浓度显著升高,而2型糖尿病组内肥胖与非肥胖者之间瘦素质量浓度差异无显著性。结论肥胖者大多存在胰岛素抵抗;2型糖尿病人无论肥胖与否均存在一定程度的胰岛素抵抗。 |
| 关 键 词： | 瘦素 肥胖 胰岛素抵抗 糖尿病 |
| 文章编号： | 1005-2194(2005)11-0992-02 |
| 修稿时间： | 2005-04-12 |
The relationship between serum Leptin concentration and insulin resistance in type 2 diabetes |
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| Zhou Yaru,Wang Zhanjian,Pang Jianhua,et al.. The relationship between serum Leptin concentration and insulin resistance in type 2 diabetes[J]. Chinese Journal of Practical Internal Medicine, 2005, 25(11): 992-993 | |
| Authors: | Zhou Yaru Wang Zhanjian Pang Jianhua et al. |
| Affiliation: | Zhou Yaru,Wang Zhanjian,Pang Jianhua,et al.Department of Endocrinology,the Third Hospital of Hebei Medical University,Shijiazhuang 050051,China |
| Abstract: | Objective To investigate the relationship between serum Leptin levels and insulin resistance.Methods During 2001-10~2002-08 fasting serum Leptin concentrations were measured with RIA in 196 cases(including 118 type 2 diabetes,78 controls),and height,body weight were measured to calculate body mass index(BMI).Results HbA_1c,SBP,TG,Leptin were correlated with ISI,Leptin concentration were higher in type 2 diabetes than in controls;Leptin concentration was significantly increased in obese subjects,whereas in type 2 diabetes serum Leptin concentration had no significant difference between obese subjects and non-obese subjects.Conclusion Most of obeses subjects have insulin resistance,whether obesity or not,the patients type 2 diabetes have some kind of insulin resistance. |
| Keywords: | Leptin Obesity Insulin resistance Diabetes |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |