| 神经干细胞分化与bHLH转录调控因子 |
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| 引用本文： | 唐珂 景乃禾. 神经干细胞分化与bHLH转录调控因子[J]. 中国神经科学杂志, 2000, 16(4): 360-364 |
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| 作者姓名： | 唐珂 景乃禾 |
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| 作者单位： | [1]中国科学院上海生物化学研究所上海生命科学研究中心 [2]上海 |
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| 基金项目： | 国家自然科学基金资助项目!(39870 2 83,39930 0 90 ) |
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| 摘 要： | 近年来,许多bHLH转录调控因子被克隆。研究揭示,bHLH转录调控因子参与了中枢神经系统神经干细胞的分化。根据bHLH转录调控因子在神经分化过程中的作用,它们可分为决定因子和分化因子。此外,有负调控因子调控bHLH蛋白参与神经干细胞分化。
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| 关 键 词： | bHLH转录调控因子 神经干细胞 细胞分化 |
The differentiation of neural stem cell and basic helix-loop-helix transcription factors |
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| TANG Ke,JING Nai he. The differentiation of neural stem cell and basic helix-loop-helix transcription factors[J]. Neuroscience Bulletin, 2000, 16(4): 360-364 |
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| Authors: | TANG Ke JING Nai he |
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| Abstract: | Recently many basic helix loop helix(bHLH) transcription factors have been cloned.Several major advances reveal that bHLH transcription factors regulate the differentiation of neural stem cells in vertebrate.Depending on their action timing during the neural differentiation process,they can be divided into either determination factors or differentation factors.In addition,some negative regulators may affect the differentiation of neural stem cells. |
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| Keywords: | bHLH transcription factor differentiation of neural stem cell determination factor differentiation factor negative regulator |
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