Reliability of the cardiac output measurement with the indirect Fick-principle for CO2 during exercise期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Reliability of the cardiac output measurement with the indirect Fick-principle for CO2 during exercise

Authors:	C. L. A. van Herwaarden R. A. Binkhorst J. F. M. Fennis A. van't Laar

Affiliation:	(1) Out-patient Clinic, Department of Medicine, University of Nijmegen, The Netherlands;(2) Section for Physiology of Exercise, Laboratory of Physiology, University of Nijmegen, The Netherlands;(3) Present address: Department of Pulmonary diseases, University of Nijmegen, Medisch Centrum Dekkerswald, Groesbeek, The Netherlands

Abstract:	Cardiac output measurements were performed during 50 exercise tests in 16 normal subjects employing the indirect Fick principle for CO₂. During sub-maximal steady state exercise the plateau CO₂ tension ( $P_{plat CO_2 }$ ) was estimated with a rebreathing procedure. The mixed venous CO₂ tension ( $P_{bar v CO_2 }$ ) was calculated by subtracting the alveolocapillary CO₂ tension difference from the $P_{plat CO_2 }$ . Compared with data from the literature the most valid calculation of the cardiac output was obtained by using the $P_{bar v CO_2 }$ . Cardiac output values, calculated via the $P_{plat CO_2 }$ turned out to be too low.The reproducibility was tested by repitition of 18 exercise tests at least after 5 days. The relative standard error of a single observation was 4.1% for the cardiac output, which was found to be as good as that of invasive measurements.

Keywords:	Cardiac output CO₂ rebreathing Exercise
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