4—16周龄高血压大鼠脑与脊髓苯环利定受体的变化(英文)

目的:研究高血压大鼠(SHR)脑和胸髓中苯环利定受体密度变化与高血压发生的关系.方法:4,8,12,16周大鼠中枢中[~3H]Phe标记的苯环利定受体密度用放射自显影法检测.结果:高血压稳定期(12,16周),SHR海马和胸髓背角中苯环利定受体明显少于非高血压大鼠(WKY);而血压升高前,4周的SHR则相反;8周血压开始上升时,SHR海马苯环利定受体增加,而在背角无差别.结论:苯环利定受体可能参与了SHR的发病过程.

Phencyclidine receptors in brain and spinal cord of spontaneously hypertensive rats aged 4-16 wk

AIM: To study the relationship between the density of phencyclidine [1-(1-phenylcyclo-hexyl)piperidine hydrochloride, Phe] receptor binding sites in brain and thoracic spinal cord (T4-6) and the development of hypertension in spontaneously hypertensive rat (SHR). METHODS: The density of Phe binding sites was determined by autoradiography using [3H]Phe in 4-, 8-, 12- and 16-wk-old rats. RESULTS: There were fewer Phe binding sites in the hippocampus and dorsal horn of thoracic spinal cord of SHR at 12 and 16 wk (P<0. 01), when hypertension has established ; while at 4 wk of age, before the development of hypertension, more Phe binding sites were found in SHR. As blood pressure began to rise at 8 wk, SHR had more Phe binding sites in hippocampus vs WKY, but no difference was seen between 2 strains in the dorsal horn of thoracic spinal cord. CONCLUSION: Phe receptors might be involved in the genesis of SHR hypertension.