足细胞凋亡在糖尿病肾病发病中的作用

糖尿病肾病是糖尿病患者最常见的慢性并发症之一,也是导致终末期肾衰竭的重要原因。近年研究发现,作为肾小球滤过屏障结构成分的足细胞在糖尿病肾病发生发展过程中起重要作用。多种因素如糖脂毒性、血管紧张素、糖基化终末产物等可引起足细胞的凋亡,促使糖尿病肾病的发生。

The Role of Podocytes Apoptosis in Diabetic Nephropathy

Diabetic nephropathy is one of the most common chronic complications,leading to end-stage renal failure.Recent studies found that the podocyte as a structural component of glomerular filtration barrier play an important role in the development of DN.A variety of factors such as glucose and lipid toxicity,angiotensin,AGEs can cause apoptosis of podocytes to promote the occurrence of DN.