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CD4~+ CD25~+调节性T细胞在上皮性卵巢癌患者外周血中的表达及临床意义
引用本文:田庚,张炜阳,赵艳晖,卢雪红,朱凤全. CD4~+ CD25~+调节性T细胞在上皮性卵巢癌患者外周血中的表达及临床意义[J]. 中国妇幼保健, 2007, 22(11): 1499-1501
作者姓名:田庚  张炜阳  赵艳晖  卢雪红  朱凤全
作者单位:1. 吉林大学第二医院妇产科,吉林,长春,130041
2. 吉林大学第二医院肾内科
摘    要:
目的:研究上皮性卵巢癌患者外周血中CD4+ CD25+调节性T细胞数量及其相关基因Foxp3 mRNA的表达特点,探讨CD4+CD25+调节性T细胞在诱导肿瘤免疫耐受中的作用。方法:采用流式细胞术检测卵巢浆液性囊腺癌和粘液性囊腺癌患者外周血中CD4+ CD25+调节性T细胞数量变化;采用半定量RT-PCR方法检测卵巢浆液性囊腺癌和粘液性囊腺癌患者外周血PBMC中Foxp3 mRNA表达水平。结果:卵巢浆液性囊腺癌和粘液性囊腺癌患者外周血中CD4+CD25+调节性T细胞数量均明显升高(P<0.05);Foxp3 mRNA在卵巢浆液性囊腺癌和粘液性囊腺癌患者外周血PBMC中表达明显增高(P<0.05)。结论:CD4+ CD25+调节性T细胞可能在卵巢癌免疫耐受中发挥重要作用。

关 键 词:CD4+ CD25+  调节性T细胞  Foxp3  肿瘤免疫
文章编号:1001-4411(2007)11-1499-03
修稿时间:2007-03-05

The changes of CD4+CD25+ T cells and expression of Foxp3 mRNA in peripheral blood mononuclear cell from patients with epithelial ovarian tumor
TIAN Geng,ZHANG Wei-Yang,ZHAO Yan-Hui,LU Xue-Hong,ZHU Feng-Quan. The changes of CD4+CD25+ T cells and expression of Foxp3 mRNA in peripheral blood mononuclear cell from patients with epithelial ovarian tumor[J]. Maternal and Child Health Care of China, 2007, 22(11): 1499-1501
Authors:TIAN Geng  ZHANG Wei-Yang  ZHAO Yan-Hui  LU Xue-Hong  ZHU Feng-Quan
Affiliation:Department of Gynecology and Obstetrics, Second Hospital, Jilin University, Changchun 130041, China
Abstract:
Objective:To investigate the changes of CD4 CD25 regulator T cells and Foxp3 mRNA in peripheral blood from the patients with epithelial ovarian tumor.Methods:Flow cytometry was used to analyze the contents of CD4 CD25 T cells in peripheral blood mononuclear cells from patients with serous cystadenocarcinoma,mucinous cystadenocarcinoma and patients without cancer as controls.The expression of Foxp3 mRNA in peripheral blood mononuclear cell was detected by RT-PCR.Results:The population of CD4 CD25 T cells in peripheral blood mononuclear cell from patients with serous cystadenocarcinoma,mucinous cystadenocarcinoma was significantly higher in comparison with that of controls.The expression of Foxp3 in peripheral blood mononuclear enhanced in patients with tumor comparison with that of controls.Conclusion:CD4 CD25 regulator T cell may play a important role in the immune tolerance.
Keywords:CD4 CD25   Foxp3
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