Discovery and Development of LX7101, a Dual LIM-Kinase
and ROCK Inhibitor for the Treatment of Glaucoma |
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| Authors: | Bryce A. Harrison,Zheng Y. Almstead,Hugh Burgoon,Michael Gardyan,Nicole C. Goodwin,Jason Healy,Ying Liu,Ross Mabon,Brett Marinelli,Lakshman Samala,Yulian Zhang,Terry R. Stouch,N. Andrew Whitlock,Suma Gopinathan,Beth McKnight,Shuli Wang,Nita Patel,Alan G. E. Wilson,Brian D. Hamman,Dennis
S. Rice,David B. Rawlins |
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| Affiliation: | †Department of Medicinal Chemistry, Lexicon Pharmaceuticals, 350 Carter Road, Princeton, New Jersey 08540, United States;‡Department of Pharmaceutical Discovery, §Department of Drug Metabolism, Pharmacokinetics, and Toxicology and ∥Department of Ophthalmology, Lexicon Pharmaceuticals, 8800 Technology Forest Place, The Woodlands, Texas 77381, United States |
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| Abstract: | ![]()
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| Keywords: | LX7101 glaucoma kinase ROCK inhibitor LIM-kinase |
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